T J Vyse
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Explore the profile of T J Vyse including associated specialties, affiliations and a list of published articles.
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53
Citations
1283
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Recent Articles
1.
Roberts A, Furnrohr B, Vyse T, Rhodes B
Clin Exp Immunol
. 2016 Apr;
185(3):361-71.
PMID: 27118513
Complement receptor 3 (CR3, CD11b/CD18) is a multi-functional receptor expressed predominantly on myeloid and natural killer (NK) cells. The R77H variant of CD11b, encoded by the ITGAM rs1143679 polymorphism, is...
2.
Armstrong D, Zidovetzki R, Alarcon-Riquelme M, Tsao B, Criswell L, Kimberly R, et al.
Genes Immun
. 2014 May;
15(6):347-54.
PMID: 24871463
In a genome-wide association study (GWAS) of individuals of European ancestry afflicted with systemic lupus erythematosus (SLE) the extensive utilization of imputation, step-wise multiple regression, lasso regularization and increasing study...
3.
Morris D, Fernando M, Taylor K, Chung S, Nititham J, Alarcon-Riquelme M, et al.
Genes Immun
. 2014 Mar;
15(4):210-7.
PMID: 24598797
Systemic lupus erythematosus (SLE) is a clinically heterogeneous disease affecting multiple organ systems and characterized by autoantibody formation to nuclear components. Although genetic variation within the major histocompatibility complex (MHC)...
4.
Bentham J, Vyse T
Lupus
. 2013 Oct;
22(12):1205-13.
PMID: 24097992
In this review, we explain the motivation for carrying out genome-wide association studies (GWAS), contrasting the achievements of linkage-based experiments for Mendelian traits with the difficulties found when applying that...
5.
Wang S, Adrianto I, Wiley G, Lessard C, Kelly J, Adler A, et al.
Genes Immun
. 2012 Apr;
13(5):380-7.
PMID: 22476155
Systemic lupus erythematosus (SLE) is an autoimmune disease with diverse clinical manifestations characterized by the development of pathogenic autoantibodies manifesting in inflammation of target organs such as the kidneys, skin...
6.
Lin C, Adrianto I, Lessard C, Kelly J, Kaufman K, Guthridge J, et al.
Genes Immun
. 2011 Dec;
13(3):232-8.
PMID: 22189356
Systemic lupus erythematosus (SLE) is a complex autoimmune disease characterized by autoantibody production and organ damage. Lupus nephritis (LN) is one of the most severe manifestations of SLE. Multiple studies...
7.
Namjou B, Kothari P, Kelly J, Glenn S, Ojwang J, Adler A, et al.
Genes Immun
. 2011 Jan;
12(4):270-9.
PMID: 21270825
Systemic lupus erythematosus (SLE) is a prototypic autoimmune disorder with a complex pathogenesis in which genetic, hormonal and environmental factors have a role. Rare mutations in the TREX1 gene, the...
8.
Rafiq S, Frayling T, Vyse T, Cunninghame Graham D, Eggleton P
Clin Exp Immunol
. 2010 Jun;
161(2):284-9.
PMID: 20528885
Recent studies have tested genetic variation at the C1QA, C1QB and C1QC (complement component 1, q subcomponent, A chain, complement component 1, q subcomponent, B chain and complement component 1,...
9.
Armstrong D, Reiff A, Myones B, Quismorio Jr F, Klein-Gitelman M, McCurdy D, et al.
Genes Immun
. 2009 May;
10(5):446-56.
PMID: 19440200
In our earlier study, we utilized a Bayesian design to probe the association of approximately 1000 genes (approximately 10,000 single-nucleotide polymorphisms (SNPs)) with systemic lupus erythematosus (SLE) on a moderate...
10.
Morris D, Graham R, Erwig L, Gaffney P, Moser K, Behrens T, et al.
Genes Immun
. 2009 May;
10(5):404-13.
PMID: 19404301
Systemic lupus erythematosus (SLE) is a complex autoimmune disease. Genome-wide linkage studies implicated a region containing the adhesion molecule P-Selectin. This family-based study revealed two regions of association within P-Selectin....