T J McKearn
Overview
Explore the profile of T J McKearn including associated specialties, affiliations and a list of published articles.
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Articles
38
Citations
374
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Recent Articles
1.
McKearn T
Cancer
. 1993 Jun;
71(12 Suppl):4302-13.
PMID: 8508392
Seventeen years after the development of hybridoma technology, the clinical utility of radioimmunodetection of solid tumors using monoclonal antibody-based imaging agents has been definitively established. As expected, these first immunoscintigraphy...
2.
3.
Alvarez V, Lopes A, Rodwell J, McKearn T, Stuart F
Targeted Diagn Ther
. 1989 Jan;
2:99-118.
PMID: 2519552
Site-specific covalent modification of monoclonal antibodies at the oligosaccharide offers advantages over more conventional modification processes that involve direct attachment at tyrosine, lysine or glutamic/aspartic acid side chains. Using the...
4.
Simonson R, Ultee M, Long C, GILLETTE R, McKearn T, Rodwell J
Clin Chem
. 1988 Sep;
34(9):1713-6.
PMID: 2970898
Labeling an antibody site specifically through its carbohydrate residues preserves more of its antigen-binding activity than does labeling through protein moieties. To boost the amount of immunoglobulin G carbohydrate capable...
5.
Alvarez V, Lopes A, Lee C, Coughlin D, Rodwell J, McKearn T
Targeted Diagn Ther
. 1988 Jan;
1:283-315.
PMID: 2979060
No abstract available.
6.
Rodwell J, Alvarez V, Lee C, Lopes A, Goers J, KING H, et al.
Proc Natl Acad Sci U S A
. 1986 Apr;
83(8):2632-6.
PMID: 3458222
A strategy for covalent modification of monoclonal antibodies utilizing the oxidized oligosaccharide moieties on the molecule was evaluated and compared to more conventional methods. As judged by quantitative in vitro...
7.
Alvarez V, Wen M, Lee C, Lopes A, Rodwell J, McKearn T
Int J Rad Appl Instrum B
. 1986 Jan;
13(4):347-52.
PMID: 3793488
Site-specific modification of monoclonal antibodies at their oligosaccharide had previously been demonstrated to produce excellent 111In imaging in a xenograft model using a Brown Norway (BN) rat lymphoma and a...
8.
Hickey W, Lee V, Trojanowski J, McMillan L, McKearn T, GONATAS J, et al.
J Histochem Cytochem
. 1983 Sep;
31(9):1126-35.
PMID: 6193166
Four monoclonal antibodies against guinea pig myelin basic protein (MBP), and four against subunits of bovine neurofilament triplet proteins (NF) were produced and their activity determined by enzyme-linked immunosorbant assay....
9.
Boyd H, POTTER T, Rajan T, ZMIJEWSKI C, McKearn T
Immunogenetics
. 1983 Jan;
18(2):183-7.
PMID: 6604022
No abstract available.
10.
Klinman D, Smilek D, McKearn T
J Immunol
. 1982 Sep;
129(3):1204-8.
PMID: 6179998
Sixteen Lewis anti-Brown Norway monoclonal antibodies and sera from alloimmunized Lewis rats were used to study the topographic relationships of antigenic determinants on class I major histocompatibility gene products. Only...