T J McIntosh
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Explore the profile of T J McIntosh including associated specialties, affiliations and a list of published articles.
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99
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Recent Articles
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Rawicz W, Smith B, McIntosh T, Simon S, Evans E
Biophys J
. 2008 Mar;
94(12):4725-36.
PMID: 18339739
Bilayers composed of phosphatidylcholine (PC), sphingomyelin (SM), and cholesterol (CHOL) are commonly used as systems to model the raft-lipid domain structure believed to compartmentalize particular cell membrane proteins. In this...
3.
Tallman K, Kim H, Ji J, Szapacs M, Yin H, McIntosh T, et al.
Chem Res Toxicol
. 2007 Feb;
20(2):227-34.
PMID: 17305406
Oxidative stress gives rise to a number of electrophilic aldehydes from membrane phospholipids, and these compounds have been linked to pathophysiologic events associated with the progression of cardiovascular disease. A...
4.
Gandhavadi M, Allende D, Vidal A, Simon S, McIntosh T
Biophys J
. 2002 Feb;
82(3):1469-82.
PMID: 11867462
Lipid bilayers composed of unsaturated phosphatidylcholine (PC), sphingomyelin (SM), and cholesterol are thought to contain microdomains that have similar detergent insolubility characteristics as rafts isolated from cell plasma membranes. We...
5.
McIntosh T, Vidal A, Simon S
Biochem Soc Trans
. 2001 Aug;
29(Pt 4):594-8.
PMID: 11498034
The interactions between a signal peptide and a variety of lipid bilayers have been studied with direct binding assays, CD and isothermal titration calorimetry. We find that the binding of...
6.
McIntosh T, Lin H, Li S, Huang C
Biochim Biophys Acta
. 2001 May;
1510(1-2):219-30.
PMID: 11342160
Previous studies from our laboratories have delineated the relationship between the acyl chain asymmetry of mixed-chain phosphatidylcholines, C(X):C(Y)PC, and the effect of ethanol concentration, [EtOH], on the main phase transition...
7.
Haque M, McIntosh T, Lentz B
Biochemistry
. 2001 Apr;
40(14):4340-8.
PMID: 11284690
Poly(ethylene glycol) (PEG)-mediated fusion of phosphatidylcholine model membranes has been shown to mimic the protein-mediated biomembrane process [Lee, J., and Lentz, B. R. (1998) Proc. Natl. Acad. Sci. U.S.A. 95,...
8.
Tarahovsky Y, Arsenault A, Macdonald R, McIntosh T, Epand R
Biophys J
. 2000 Dec;
79(6):3193-200.
PMID: 11106623
A regular progression of polymorphic phase behavior was observed for mixtures of the anionic phospholipid, cardiolipin, and the cationic phospholipid derivative, 1, 2-dioleoyl-sn-glycero-3-ethylphosphocholine. As revealed by freeze-fracture electron microscopy and...
9.
Preparation and preclinical evaluation of a novel liposomal complete-core lipopolysaccharide vaccine
Bennett-Guerrero E, McIntosh T, Barclay G, Snyder D, Gibbs R, Mythen M, et al.
Infect Immun
. 2000 Oct;
68(11):6202-8.
PMID: 11035726
Our objective is to develop a prophylactic vaccine strategy that can be evaluated for surgical and other high-risk hospitalized patients. In this paper, we describe the preparation and preclinical evaluation...
10.
Snyder D, McIntosh T
Biochemistry
. 2000 Sep;
39(38):11777-87.
PMID: 10995246
Lipopolysaccharide (LPS), the primary lipid on the surface of Gram-negative bacteria, is thought to act as a permeability barrier, making the outer membrane relatively impermeable to hydrophobic antibiotics, detergents, and...