T J Jacob
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Explore the profile of T J Jacob including associated specialties, affiliations and a list of published articles.
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51
Citations
338
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Recent Articles
1.
Wang L, Chen L, Jacob T
J Physiol
. 2000 Apr;
524 Pt 1:63-75.
PMID: 10747184
1. A chloride current with mild outward rectification was induced in the native bovine non-pigmented ciliary epithelial (NPCE) cells by a 23 % hypotonic solution. The current showed no or...
2.
Walker V, Stelling J, Miley H, Jacob T
Am J Physiol
. 1999 Jun;
276(6):C1432-8.
PMID: 10362607
The ciliary epithelium of the eye secretes the aqueous humor. It is a double epithelium arranged so that the apical surfaces of the nonpigmented ciliary epithelial (NPCE) and pigmented ciliary...
3.
Jacob T
Prog Retin Eye Res
. 1999 Feb;
18(2):223-33.
PMID: 9932284
The cause of cataracts is not known. Data from epidemiological and case-control studies have suggested various risk factors, among them; sunlight, diabetes, diarrhoea, oxidative stress, smoking and alcohol. Many reports...
4.
Chen L, Wang L, Jacob T
Am J Physiol
. 1999 Jan;
276(1):C182-92.
PMID: 9886934
We investigated the relationship between pICln, the volume-activated Cl- current, and volume regulation in native bovine nonpigmented ciliary epithelial (NPCE) cells. Immunofluorescence studies demonstrated the presence of pICln protein in...
5.
Wang L, Chen L, Walker V, Jacob T
J Physiol
. 1998 Jul;
511 ( Pt 1):33-44.
PMID: 9679161
Native ciliary epithelial cells from the ciliary epithelium of the eye exhibit anti-P-glycoprotein (P-gp) immunofluorescence. We have used an antisense 'knock-down' approach to investigate the relationship between P-gp and the...
6.
Stelling J, Jacob T
Am J Physiol
. 1998 Jan;
273(6):C1876-81.
PMID: 9435492
The functional coupling of the ciliary epithelium was studied in isolated pairs (couplets) of pigmented ciliary epithelial (PCE) and nonpigmented ciliary epithelial (NPCE) cells using the whole cell patch clamp...
7.
Mitchell C, Wang L, Jacob T
J Membr Biol
. 1997 Jul;
158(2):167-75.
PMID: 9230094
A large-conductance (or maxi-) chloride channel was identified in bovine pigmented ciliary epithelial (PCE) cells using inside-out excised patch clamp recording. The channel had a mean conductance of 293 pS...
8.
Zhang J, Jacob T
Exp Physiol
. 1997 Mar;
82(2):245-59.
PMID: 9129939
Until recently, the investigation of membrane ion transport mechanisms and their relationship with cataract formation has mainly focused on sodium, potassium and calcium. The specific role of chloride in solute...
9.
Zhang J, Jacob T
J Physiol
. 1997 Mar;
499 ( Pt 2):379-89.
PMID: 9080368
1. Hypotonic solution induced transient Cl- channel activity in both pigmented and non-pigmented ciliary epithelial cells in cell-attached patches. 2. The activation time constants for these currents were 63 and...
10.
Mitchell C, Zhang J, Wang L, Jacob T
Am J Physiol
. 1997 Jan;
272(1 Pt 1):C212-22.
PMID: 9038827
The whole cell recording technique was used to examine an outwardly rectifying chloride current activated by hypotonic shock in bovine pigmented ciliary epithelial (PCE) cells. Removal of internal and external...