T Hugel
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Explore the profile of T Hugel including associated specialties, affiliations and a list of published articles.
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Articles
9
Citations
205
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Recent Articles
1.
Tschaikowsky M, Selig M, Brander S, Balzer B, Hugel T, Rolauffs B
Osteoarthritis Cartilage
. 2020 Nov;
29(2):269-279.
PMID: 33220445
Objective: Clinical trials for osteoarthritis (OA), the leading cause of global disability, are unable to pinpoint the early, potentially reversible disease with clinical technology. Hence, disease-modifying drug candidates cannot be...
2.
A Multicolor Single-Molecule FRET Approach to Study Protein Dynamics and Interactions Simultaneously
Gotz M, Wortmann P, Schmid S, Hugel T
Methods Enzymol
. 2016 Oct;
581:487-516.
PMID: 27793290
Single-molecule Förster resonance energy transfer (smFRET) is a versatile tool for studying biomolecules in a quantitative manner. Multiple conformations within and interactions between biomolecules can be detected and their kinetics...
3.
Boettcher K, Kienle S, Nachtsheim J, Burgkart R, Hugel T, Lieleg O
Acta Biomater
. 2015 Oct;
29:180-187.
PMID: 26432435
Statement Of Significance: We here demonstrate the sturdiness of articular cartilage towards changes in fluid content and show that articular cartilage recovers a broad range of its material properties after...
4.
Ratzke C, Hellenkamp B, Hugel T
Nat Commun
. 2014 Jun;
5:4192.
PMID: 24947016
In living organisms, most proteins work in complexes to form multicomponent protein machines. The function of such multicomponent machines is usually addressed by dividing them into a collection of two...
5.
Hugel T, Zols S, Palzer A, Kaufmann S, Langhoff R, Ritzmann M, et al.
Tierarztl Prax Ausg G Grosstiere Nutztiere
. 2011 Dec;
39(6):353-7.
PMID: 22167079
Objective: The effects of vaccination against gonadotropin releasing factor (GnRF) with Improvac® (Pfizer Animal Health) were compared with surgical castration in fattening pigs. Material And Methods: A total of 205...
6.
Ratzke C, Mickler M, Hellenkamp B, Buchner J, Hugel T
Proc Natl Acad Sci U S A
. 2010 Aug;
107(37):16101-6.
PMID: 20736353
The molecular chaperone heat shock protein 90 (Hsp90) is an important and abundant protein in eukaryotic cells, essential for the activation of a large set of signal transduction and regulatory...
7.
Pirzer T, Geisler M, Scheibel T, Hugel T
Phys Biol
. 2009 Jul;
6(2):025004.
PMID: 19571365
In this paper we probe the influence of surface properties, pH and salt on the adhesion of recombinant spider silk proteins onto solid substrates with single molecule force spectroscopy. A...
8.
Horinek D, Serr A, Geisler M, Pirzer T, Slotta U, Lud S, et al.
Proc Natl Acad Sci U S A
. 2008 Feb;
105(8):2842-7.
PMID: 18287007
The hydrophobic effect, i.e., the poor solvation of nonpolar parts of molecules, plays a key role in protein folding and more generally for molecular self-assembly and aggregation in aqueous media....
9.
Urry D, Hugel T, Seitz M, Gaub H, Sheiba L, Dea J, et al.
Philos Trans R Soc Lond B Biol Sci
. 2002 Mar;
357(1418):169-84.
PMID: 11911774
During the last half century, identification of an ideal (predominantly entropic) protein elastomer was generally thought to require that the ideal protein elastomer be a random chain network. Here, we...