T H Roderick
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Explore the profile of T H Roderick including associated specialties, affiliations and a list of published articles.
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99
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2272
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Recent Articles
1.
Chang B, Hawes N, Hurd R, Wang J, Howell D, Davisson M, et al.
Vis Neurosci
. 2005 Dec;
22(5):587-93.
PMID: 16332269
The Jackson Laboratory, having the world's largest collection of mouse mutant stocks and genetically diverse inbred strains, is an ideal place to discover genetically determined eye variations and disorders. In...
2.
Klebanov S, Flurkey K, Roderick T, Archer J, Astle M, Chen J, et al.
Genetica
. 2002 Jan;
110(3):209-18.
PMID: 11766841
We found high narrow-sense heritability of life span based on the regression of offspring on average parental (midparent) life spans. In two mouse populations prepared using the 4-way-cross design, mean...
3.
Klebanov S, Astle C, Roderick T, Flurkey K, Archer J, Chen J, et al.
Exp Biol Med (Maywood)
. 2001 Sep;
226(9):854-9.
PMID: 11568309
The genes that control basic aging mechanisms in mammals are unknown. By using two four-way crosses, each including a strain derived from wild, undomesticated stocks, we identified two quantitative trait...
4.
Cook S, Akeson E, Calvano C, Johnson K, MANDELL J, Hawes N, et al.
Cytogenet Cell Genet
. 2001 Jul;
93(1-2):77-82.
PMID: 11474184
The paracentric inversion In(3)55Rk on mouse Chromosome 3 (Chr 3) was induced by cesium irradiation. Genetic crosses indicate the proximal breakpoint cosegregates with D3Mit324 and D3Mit92; the distal breakpoint cosegregates...
5.
Hawes N, Chang B, Hageman G, Nusinowitz S, Nishina P, Schneider B, et al.
Invest Ophthalmol Vis Sci
. 2000 Sep;
41(10):3149-57.
PMID: 10967077
Purpose: To characterize the genetics and phenotype of a new mouse mutant with retinal degeneration, rd6, that is associated with extensive, scattered, small white retinal dots seen ophthalmoscopically. Methods: The...
6.
Akhmedov N, Piriev N, Chang B, Rapoport A, Hawes N, Nishina P, et al.
Proc Natl Acad Sci U S A
. 2000 May;
97(10):5551-6.
PMID: 10805811
The rd7 mouse, an animal model for hereditary retinal degeneration, has some characteristics similar to human flecked retinal disorders. Here we report the identification of a deletion in a photoreceptor-specific...
7.
Smith R, Hawes N, Chang B, Roderick T, Akeson E, Heckenlively J, et al.
Genomics
. 2000 Mar;
63(3):314-20.
PMID: 10704279
A new cataract mutation was discovered in an ongoing program to identify new mouse models of hereditary eye disease. Lens opacity 12 (Lop12) is a semidominant mutation that results in...
8.
Chang B, Hawes N, Roderick T, Smith R, Heckenlively J, Horwitz J, et al.
Mol Vis
. 1999 Sep;
5:21.
PMID: 10493778
Purpose: The mouse lop18 (lens opacity 18) mutation causes a white cataract obvious at weaning age. It soon progresses to a large white nuclear cataract with mild cortical changes. The...
9.
Chang B, Smith R, Hawes N, Anderson M, Zabaleta A, Savinova O, et al.
Nat Genet
. 1999 Apr;
21(4):405-9.
PMID: 10192392
Glaucomas are a major cause of blindness. Visual loss typically involves retinal ganglion cell death and optic nerve atrophy subsequent to a pathologic elevation of intraocular pressure (IOP). Some human...
10.
John S, Smith R, Savinova O, Hawes N, Chang B, Turnbull D, et al.
Invest Ophthalmol Vis Sci
. 1998 May;
39(6):951-62.
PMID: 9579474
Purpose: To characterize ocular abnormalities associated with iris atrophy in DBA/2J mice and to determine whether mice of this strain develop elevated intraocular pressure (IOP) and glaucoma. Methods: Different approaches,...