T G Gantchev
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Explore the profile of T G Gantchev including associated specialties, affiliations and a list of published articles.
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18
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90
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Recent Articles
1.
Gantchev T, Ouellet R, van Lier J
Arch Biochem Biophys
. 1999 May;
366(1):21-30.
PMID: 10334859
Phthalocyanines (Pc), which are extensively studied as tumor localizing photosensitizers for photodynamic therapy, are transported by the blood circulatory system to target tissues. Binding interactions between human serum albumin and...
2.
Gantchev T, Hunting D
Mol Pharmacol
. 1998 Apr;
53(3):422-8.
PMID: 9495807
Epipodophyllotoxin derivatives, such as etoposide (VP-16), constitute an important class of anticancer agents, the major cytotoxic effects of which are associated with trapping of the topoisomerase II/DNA cleavable complex and...
3.
Gantchev T, Hunting D
Biochem Biophys Res Commun
. 1997 Aug;
237(1):24-7.
PMID: 9266822
Etoposide (VP-16) is a widely used anticancer drug whose toxicity involves poisoning of topoisomerase II. VP-16 undergoes enzymatic oxido-reductive transformations in cells, resulting in the formation of the ortho-quinone derivative...
4.
Gantchev T, Hunting D
Anticancer Drugs
. 1997 Feb;
8(2):164-73.
PMID: 9073312
The effects of glutathione (GSH) depletion by buthionine sulfoximane (BSO) or by photosensitization-induced oxidative stress using metallo-phthalocyanines (MePcS4) on etoposide (VP-16) cytotoxicity against K562 human leukemic cells were investigated. Both...
5.
Gantchev T, Brasseur N, van Lier J
Br J Cancer
. 1996 Nov;
74(10):1570-7.
PMID: 8932337
Etoposide (VP-16) is an anti-cancer drug commonly used against several types of tumours and leukaemia, either alone or in combination chemotherapy. Photodynamic therapy (PDT) is another, relatively new modality for...
6.
Gantchev T, van Lier J
Photochem Photobiol
. 1995 Jul;
62(1):123-34.
PMID: 7638256
Catalase (CAT) in solution or incorporated in erythrocytes and K562 leukemic cells is inactivated during photosensitization with tetrasulfonated metallophthalocyanines (MePcS4). The effect of added scavengers and D2O showed that both...
7.
Gantchev T
Int J Radiat Biol
. 1995 Jul;
68(1):29-36.
PMID: 7629435
In order to obtain information concerning the mechanism(s) of metallo-phthalocyanine (MePcS4) photosensitized damage of DNA constituents, the EPR-spin trapping method in conjunction with liquid chromatography was used to study thymidine...
8.
Gantchev T, Gowans B, Hunting D, Wagner J, van Lier J
Int J Radiat Biol
. 1994 Dec;
66(6):705-16.
PMID: 7814970
Photoirradiation of aqueous solutions of DNA in the presence of Al- or Zn-tetrasulphonated phthalocyanines (AIPcS4 and ZnPcS4) causes formation of strand breaks and liberation of nucleobases. The effect of added...
9.
Gantchev T, Ali H, van Lier J
J Med Chem
. 1994 Nov;
37(24):4164-76.
PMID: 7990116
The 3-D quantitative structure-activity relationships/comparative molecular field analysis (QSAR/CoMFA) paradigm, which considers the primary importance of the molecular fields in biological recognition, is now widely used to analyze and predict...
10.
Kagan V, Yalowich J, Day B, Goldman R, Gantchev T, Stoyanovsky D
Biochemistry
. 1994 Aug;
33(32):9651-60.
PMID: 8068642
Phenoxyl radicals are intermediates in the oxidation of phenolic compounds to quinoid derivatives (quinones, quinone methides), which are known to act as ultimate mutagenic, carcinogenic, and cytotoxic agents by directly...