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T F Danna

Explore the profile of T F Danna including associated specialties, affiliations and a list of published articles. Areas
Snapshot
Articles 8
Citations 40
Followers 0
Related Specialties
Genetics
Oncology
Geriatrics
Top 10 Co-Authors
K Randerath
E RANDERATH
R Reddy
W P Watson
R W Hart
K L Putman
P F Yang
M S Rao
A Turturro
G D Zhou
Published In
Mutat Res
Carcinogenesis
Mech Ageing Dev
Affiliations
Soon will be listed here.
Recent Articles
1.
Enhancement of age-related increases in DNA I-compound levels by calorie restriction: comparison of male B-N and F-344 rats
Randerath K, Hart R, Zhou G, Reddy R, Danna T, RANDERATH E
Mutat Res . 1993 Jan; 295(1):31-46. PMID: 7677927
Caloric restriction (CR), known to extend median and maximum life spans, improve resistance to carcinogenesis, and significantly retard age-associated degenerative diseases in rodents, was previously reported to modulate levels of...
2.
Formation of ribonucleotides in DNA modified by oxidative damage in vitro and in vivo. Characterization by 32P-postlabeling
Randerath K, Reddy R, Danna T, Watson W, Crane A, RANDERATH E
Mutat Res . 1992 Sep; 275(3-6):355-66. PMID: 1383776
Oxygen free radicals generated by the interaction of Fe2+ and H2O2 (Fenton reaction) are capable of reacting with DNA bases, which may induce premutagenic and precarcinogenic lesions. Products formed in...
3.
DNA damage induced by cigarette smoke condensate in vitro as assayed by 32P-postlabeling. Comparison with cigarette smoke-associated DNA adduct profiles in vivo
RANDERATH E, Danna T, Randerath K
Mutat Res . 1992 Jul; 268(1):139-53. PMID: 1378180
Cigarette smoke induces a multitude of bulky/aromatic DNA adducts in vivo as revealed by 32P-postlabeling assay. The formation of such adducts is thought to involve metabolic activation of aromatic chemicals...
4.
Bulky adducts detected by 32P-postlabeling in DNA modified by oxidative damage in vitro. Comparison with rat lung I-compounds
Randerath K, Yang P, Danna T, Reddy R, Watson W, RANDERATH E
Mutat Res . 1991 Sep; 250(1-2):135-44. PMID: 1944328
Oxygen free radicals, such as the hydroxyl radical generated by interaction of Fe2+ and H2O2 (Fenton reaction), are produced in mammalian cells as a result of aerobic metabolism and under...
5.
Effects of aging and caloric restriction on I-compounds in liver, kidney and white blood cell DNA of male Brown-Norway rats
RANDERATH E, Hart R, Turturro A, Danna T, Reddy R, Randerath K
Mech Ageing Dev . 1991 May; 58(2-3):279-96. PMID: 1875735
Rodent tissues display species-, strain-, sex- and tissue-specific adduct-like DNA modifications termed I-compounds, which increase with age, are modulated by diet and are presumably derived from indigenous metabolic intermediates. We...
6.
Induction of rat liver DNA alterations by chronic administration of peroxisome proliferators as detected by 32P-postlabeling
RANDERATH E, Randerath K, Reddy R, Danna T, Rao M, Reddy J
Mutat Res . 1991 Mar; 247(1):65-76. PMID: 2002806
The mechanisms of the hepatocarcinogenicity of non-mutagenic peroxisome proliferators, i.e. compounds used as hypolipidemic drugs and industrial plasticizers, are not sufficiently understood. To gain more information on the mechanism of...
7.
Lack of I-compounds in DNA from a spectrum of Morris hepatomas
Randerath K, RANDERATH E, Danna T
Carcinogenesis . 1990 Jun; 11(6):1041-4. PMID: 2347063
A partial, progressive loss of I-compounds (age-dependent, putative indigenous DNA modifications) has been observed recently during hepatocarcinogenesis induced in rats by 2,3,7,8-tetrachlorodibenzo-p-dioxin, choline-devoid diet or peroxisome proliferators. It was of...
8.
A new sensitive 32P-postlabeling assay based on the specific enzymatic conversion of bulky DNA lesions to radiolabeled dinucleotides and nucleoside 5'-monophosphates
Randerath K, RANDERATH E, Danna T, van Golen L, Putman K
Carcinogenesis . 1989 Jul; 10(7):1231-9. PMID: 2544310
A new sensitive 32P-postlabeling assay for DNA adducts has been developed in which DNA is hydrolyzed initially by nuclease P1 and prostatic acid phosphatase instead of micrococcal nuclease and spleen...