T E Wiese
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Explore the profile of T E Wiese including associated specialties, affiliations and a list of published articles.
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Articles
9
Citations
148
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0
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Recent Articles
1.
Burow M, Boue S, Collins-Burow B, Melnik L, Duong B, Carter-Wientjes C, et al.
J Clin Endocrinol Metab
. 2001 Apr;
86(4):1750-8.
PMID: 11297613
The flavonoid family of phytochemicals, particularly those derived from soy, has received attention regarding their estrogenic activity as well as their effects on human health and disease. In addition to...
2.
Bolger R, Wiese T, Ervin K, Nestich S, Checovich W
Environ Health Perspect
. 1998 Aug;
106(9):551-7.
PMID: 9721254
Over the last few years, an increased awareness of endocrine disrupting chemicals (EDCs) and their potential to affect wildlife and humans has produced a demand for practical screening methods to...
3.
Wiese T, Polin L, Palomino E, Brooks S
J Med Chem
. 1997 Nov;
40(22):3659-69.
PMID: 9357533
Analogues of estradiol-17 beta (E2) have been evaluated for estrogen receptor (ER) binding affinity and mitogenic potential in the human breast cancer cell line MCF-7. These 42 compounds represent subtle...
4.
Waller C, Oprea T, Chae K, Park H, Korach K, Laws S, et al.
Chem Res Toxicol
. 1996 Dec;
9(8):1240-8.
PMID: 8951225
Comparative molecular field analysis (CoMFA), a three-dimensional quantitative structure-activity relationship (3D-QSAR) paradigm, was used to examine the estrogen receptor (ER) binding affinities of a series of structurally diverse natural, synthetic,...
5.
Wiese T, Dukes D, Brooks S
Steroids
. 1995 Dec;
60(12):802-8.
PMID: 8650702
Crystallographic and computer modeling studies throughout the last 25 years have shown the structure of diethylstilbestrol (DES) to exist in two symmetrical or one asymmetrical conformation. As a result of...
6.
Molecular modeling of steroidal estrogens: novel conformations and their role in biological activity
Wiese T, Brooks S
J Steroid Biochem Mol Biol
. 1994 Jul;
50(1-2):61-73.
PMID: 8049135
Since the structure and conformation of many estrogenic ligands cannot be described with X-ray crystallographic studies, molecular modeling techniques must be used to generate their 3-dimensional structures. The potential of...
7.
HORWITZ J, Massova I, Wiese T, Besler B, Corbett T
J Med Chem
. 1994 Mar;
37(6):781-6.
PMID: 8145227
The present study establishes correlations of in vivo growth inhibition of a solid tumor, pancreatic ductal adenocarcinoma (Panc03), of mice with the steric and electrostatic fields and the hydrophobic parameter...
8.
HORWITZ J, Massova I, Wiese T, Wozniak A, Corbett T, CAPPS D, et al.
J Med Chem
. 1993 Nov;
36(23):3511-6.
PMID: 8280289
In vitro screening of a number of 2-(aminoalkyl)-5-nitropyrazolo[3,4,5- kl]acridines has previously indicated (Sebolt, J.S.; et al. Cancer Res. 1987, 47, 4299-4304) that these compounds, in general, exhibit selective cytotoxicity against...
9.
Wiese T, Kral L, Dennis K, Butler W, Brooks S
In Vitro Cell Dev Biol
. 1992 Sep;
28A(9-10):595-602.
PMID: 1429362
The factors involved in estradiol-17 beta induced growth stimulation of MCF-7 human breast cancer cells have been examined. Wild type MCF-7 cells (and clone E3) were shown to undergo slow...