T Borras
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Explore the profile of T Borras including associated specialties, affiliations and a list of published articles.
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Articles
27
Citations
480
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Recent Articles
1.
Borras T, Buie L, Spiga M
Gene Ther
. 2016 Feb;
23(5):438-49.
PMID: 26855269
Current treatment of glaucoma relies on administration of daily drops or eye surgery. A gene therapy approach to treat steroid-induced glaucoma would bring a resolution to millions of people worldwide...
2.
Borras T, Gabelt B, Klintworth G, Peterson J, Kaufman P
J Gene Med
. 2001 Oct;
3(5):437-49.
PMID: 11601757
Background: Glaucoma is a group of chronic eye diseases often associated with an elevated intraocular pressure (IOP). If not controlled, the condition leads to blindness. The eye tissue responsible for...
3.
Caballero M, Borras T
Biochem Biophys Res Commun
. 2001 Jun;
282(3):662-70.
PMID: 11401512
Mutations in TIGR/MYOC (myocilin), a secretory protein of unknown function, have been recently linked to glaucoma. Most known mutations map to the C-terminus, an olfactomedin-like domain. We have previously shown...
4.
Caballero M, Rowlette L, Borras T
Biochim Biophys Acta
. 2000 Nov;
1502(3):447-60.
PMID: 11068187
TIGR/MYOC, a novel 504 amino acids (aa) protein of unknown function, has recently been linked to glaucoma. The protein is both intra- and extracellular and most known mutations map to...
5.
Gonzalez P, Epstein D, Borras T
Invest Ophthalmol Vis Sci
. 2000 Oct;
41(12):3678-93.
PMID: 11053263
Purpose: To study the gene expression profile of the human trabecular meshwork (HTM). Methods: A polymerase chain reaction (PCR)-amplified cDNA library was constructed using RNA from the TM of a...
6.
Gonzalez P, Epstein D, Borras T
Invest Ophthalmol Vis Sci
. 2000 Feb;
41(2):352-61.
PMID: 10670462
Purpose: To identify genes upregulated in perfused, intact human trabecular meshwork (TM) in response to elevated intraocular pressure (IOP). Method: Two pairs of anterior segments of normal human eyes from...
7.
Borras T, Rowlette L, Erzurum S, Epstein D
Gene Ther
. 1999 Sep;
6(4):515-24.
PMID: 10476211
Obstruction of the aqueous humor outflow from the anterior chamber of the eye leads to an elevation of intraocular pressure in glaucoma, the second major cause of blindness worldwide. Our...
8.
Gonzalez P, Zigler Jr J, Epstein D, Borras T
Biotechniques
. 1999 May;
26(5):884-6, 888-92.
PMID: 10337481
Identification of differentially expressed genes from tissue samples weighing only a few milligrams has remained a major challenge. Here, we describe a novel and simple strategy that uses standard molecular...
9.
Borras T, Matsumoto Y, Epstein D, Johnson D
Invest Ophthalmol Vis Sci
. 1998 Jul;
39(8):1503-7.
PMID: 9660500
Purpose: To determine whether adenovirus vectors are capable of transferring a foreign active protein to the perfused anterior segment of the human eye. Methods: Primary cultures from the human trabecular...
10.
Borras T, Tamm E, Zigler Jr J
Invest Ophthalmol Vis Sci
. 1996 Jun;
37(7):1282-93.
PMID: 8641831
Purpose: To study the effects of adenoviral gene transfer to the tissues of the anterior segment in vitro by rat and monkey lens organ cultures and in vivo by single...