Sylvie M Noordermeer
Overview
Explore the profile of Sylvie M Noordermeer including associated specialties, affiliations and a list of published articles.
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Articles
23
Citations
2044
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Recent Articles
1.
Fradet-Turcotte A, Canny M, Escribano-Diaz C, Orthwein A, Leung C, Huang H, et al.
Nature
. 2025 Jan;
638(8051):E34.
PMID: 39880959
No abstract available.
2.
Orthwein A, Noordermeer S, Wilson M, Landry S, Enchev R, Sherker A, et al.
Nature
. 2025 Jan;
638(8051):844.
PMID: 39870925
No abstract available.
3.
Orthwein A, Fradet-Turcotte A, Noordermeer S, Canny M, Brun C, Strecker J, et al.
Science
. 2025 Jan;
387(6730):147.
PMID: 39787242
No abstract available.
4.
Ceppi I, Dello Stritto M, Mutze M, Braunshier S, Mengoli V, Reginato G, et al.
Nature
. 2024 Sep;
634(8033):492-500.
PMID: 39261728
DNA double-strand break (DSB) repair by homologous recombination is initiated by DNA end resection, a process involving the controlled degradation of the 5'-terminated strands at DSB sites. The breast cancer...
5.
Jadav R, Weiland F, Noordermeer S, Carroll T, Gao Y, Wang J, et al.
Mol Cell Proteomics
. 2024 Jun;
23(8):100802.
PMID: 38880245
The ATR kinase protects cells against DNA damage and replication stress and represents a promising anti-cancer drug target. The ATR inhibitors (ATRi) berzosertib and gartisertib are both in clinical trials...
6.
Schreuder A, Wendel T, Dorresteijn C, Noordermeer S
Trends Genet
. 2024 May;
40(9):757-771.
PMID: 38789375
The tumour-suppressive roles of BRCA1 and 2 have been attributed to three seemingly distinct functions - homologous recombination, replication fork protection, and single-stranded (ss)DNA gap suppression - and their relative...
7.
van de Kooij B, Schreuder A, Pavani R, Garzero V, Uruci S, Wendel T, et al.
Mol Cell
. 2024 Jan;
84(4):659-674.e7.
PMID: 38266640
Inactivating mutations in the BRCA1 and BRCA2 genes impair DNA double-strand break (DSB) repair by homologous recombination (HR), leading to chromosomal instability and cancer. Importantly, BRCA1/2 deficiency also causes therapeutically...
8.
Singh J, Noordermeer S, Jimenez-Sainz J, Maranon D, Altmeyer M
Front Genet
. 2022 Aug;
13:993889.
PMID: 36035119
No abstract available.
9.
Adam S, Rossi S, Moatti N, De Marco Zompit M, Xue Y, Ng T, et al.
Nat Cancer
. 2022 Feb;
2(12):1357-1371.
PMID: 35121901
BRCA1/2-mutated cancer cells adapt to the genome instability caused by their deficiency in homologous recombination (HR). Identification of these adaptive mechanisms may provide therapeutic strategies to target tumors caused by...
10.
Sherker A, Chaudhary N, Adam S, Heijink A, Noordermeer S, Fradet-Turcotte A, et al.
EMBO Rep
. 2021 Nov;
22(12):e53679.
PMID: 34726323
The tumor suppressor BRCA1 accumulates at sites of DNA damage in a ubiquitin-dependent manner. In this work, we revisit the role of RAP80 in promoting BRCA1 recruitment to damaged chromatin....