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» Authors » Sylvia T Nurnberg

Sylvia T Nurnberg

Explore the profile of Sylvia T Nurnberg including associated specialties, affiliations and a list of published articles. Areas
Snapshot
Articles 8
Citations 261
Followers 0
Related Specialties
Genetics
Cardiology & Vascular Diseases
Biology
Top 10 Co-Authors
Thomas Quertermous
Daniel J Rader
Berthold Gottgens
Willem H Ouwehand
Ulf Hedin
Wei Zhao
Karen Cheng
Clint L Miller
Danish Saleheen
Muredach P Reilly
Published In
PLoS Genet
Blood
Elife
Circulation
Circ Res
Affiliations
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Recent Articles
1.
Genomic profiling of human vascular cells identifies TWIST1 as a causal gene for common vascular diseases
Nurnberg S, Guerraty M, Wirka R, Rao H, Pjanic M, Norton S, et al.
PLoS Genet . 2020 Jan; 16(1):e1008538. PMID: 31917787
Genome-wide association studies have identified multiple novel genomic loci associated with vascular diseases. Many of these loci are common non-coding variants that affect the expression of disease-relevant genes within coronary...
2.
Connecting the Dots in Atrial Fibrillation
Nurnberg S
Circ Cardiovasc Genet . 2017 Oct; 10(5). PMID: 28974515
No abstract available.
3.
Loss of Cardioprotective Effects at the Locus as a Result of Gene-Smoking Interactions
Saleheen D, Zhao W, Young R, Nelson C, Ho W, Ferguson J, et al.
Circulation . 2017 May; 135(24):2336-2353. PMID: 28461624
Background: Common diseases such as coronary heart disease (CHD) are complex in etiology. The interaction of genetic susceptibility with lifestyle factors may play a prominent role. However, gene-lifestyle interactions for...
4.
An experimentally validated network of nine haematopoietic transcription factors reveals mechanisms of cell state stability
Schutte J, Wang H, Antoniou S, Jarratt A, Wilson N, Riepsaame J, et al.
Elife . 2016 Feb; 5:e11469. PMID: 26901438
Transcription factor (TF) networks determine cell-type identity by establishing and maintaining lineage-specific expression profiles, yet reconstruction of mammalian regulatory network models has been hampered by a lack of comprehensive functional...
5.
From Loci to Biology: Functional Genomics of Genome-Wide Association for Coronary Disease
Nurnberg S, Zhang H, Hand N, Bauer R, Saleheen D, Reilly M, et al.
Circ Res . 2016 Feb; 118(4):586-606. PMID: 26892960
Genome-wide association studies have provided a rich collection of ≈ 58 coronary artery disease (CAD) loci that suggest the existence of previously unsuspected new biology relevant to atherosclerosis. However, these...
6.
Coronary Artery Disease Associated Transcription Factor TCF21 Regulates Smooth Muscle Precursor Cells That Contribute to the Fibrous Cap
Nurnberg S, Cheng K, Raiesdana A, Kundu R, Miller C, Kim J, et al.
PLoS Genet . 2015 May; 11(5):e1005155. PMID: 26020946
Recent genome wide association studies have identified a number of genes that contribute to the risk for coronary heart disease. One such gene, TCF21, encodes a basic-helix-loop-helix transcription factor believed...
7.
Disease-related growth factor and embryonic signaling pathways modulate an enhancer of TCF21 expression at the 6q23.2 coronary heart disease locus
Miller C, Anderson D, Kundu R, Raiesdana A, Nurnberg S, Diaz R, et al.
PLoS Genet . 2013 Jul; 9(7):e1003652. PMID: 23874238
Coronary heart disease (CHD) is the leading cause of mortality in both developed and developing countries worldwide. Genome-wide association studies (GWAS) have now identified 46 independent susceptibility loci for CHD,...
8.
A GWAS sequence variant for platelet volume marks an alternative DNM3 promoter in megakaryocytes near a MEIS1 binding site
Nurnberg S, Rendon A, Smethurst P, Paul D, Voss K, Thon J, et al.
Blood . 2012 Sep; 120(24):4859-68. PMID: 22972982
We recently identified 68 genomic loci where common sequence variants are associated with platelet count and volume. Platelets are formed in the bone marrow by megakaryocytes, which are derived from...