Sylvia Laffer
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Explore the profile of Sylvia Laffer including associated specialties, affiliations and a list of published articles.
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14
Citations
264
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Recent Articles
1.
Schofer S, Laffer S, Kirchberger S, Kothmayer M, Lohnert R, Ebner E, et al.
Eur J Histochem
. 2024 Apr;
68(1).
PMID: 38568207
During the aging process, cells can enter cellular senescence, a state in which cells leave the cell cycle but remain viable. This mechanism is thought to protect tissues from propagation...
2.
Snyers L, Laffer S, Lohnert R, Weipoltshammer K, Schofer C
Sci Rep
. 2022 Aug;
12(1):13972.
PMID: 35978024
In this study, we characterize the changes in nucleolar morphology and its dynamics induced by the recently introduced compound CX-5461, an inhibitor of ribosome synthesis. Time-lapse imaging, immunofluorescence and ultrastructural...
3.
Zupkovitz G, Kabiljo J, Martin D, Laffer S, Schofer C, Pusch O
Dev Genes Evol
. 2018 Sep;
228(6):255-265.
PMID: 30178389
Members of the Klotho gene family have been identified as modulators of the aging process. Deletion of αklotho in the mouse results in a syndrome resembling rapid human aging. Conversely,...
4.
Snyers L, Erhart R, Laffer S, Pusch O, Weipoltshammer K, Schofer C
Eur J Cell Biol
. 2017 Dec;
97(1):63-74.
PMID: 29254732
The human LEM-domain protein family is involved in fundamental aspects of nuclear biology. The LEM-domain interacts with the barrier-to-autointegration factor (BAF), which itself binds DNA. LEM-domain proteins LAP2, emerin and...
5.
Grunt T, Hebar A, Laffer S, Wagner R, Peter B, Herrmann H, et al.
Am J Cancer Res
. 2015 May;
5(2):560-74.
PMID: 25973297
Advanced colorectal cancer is characterized by uncontrolled growth and resistance against anti-cancer agents, including ErbB inhibitors. Recent data suggest that cancer stem cells (CSC) are particularly resistant. These cells may...
6.
Karlic H, Herrmann H, Schulenburg A, Grunt T, Laffer S, Mirkina I, et al.
Wien Klin Wochenschr
. 2010 Jul;
122(13-14):423-36.
PMID: 20645015
Biological features of tumor cells relevant to progression, metastasis, and prognosis in cancer patients have been investigated for many years. During the past few years, the concept of tumor stem...
7.
Schulenburg A, Bramswig K, Herrmann H, Karlic H, Mirkina I, Hubmann R, et al.
Crit Rev Oncol Hematol
. 2010 Feb;
76(2):79-98.
PMID: 20185329
Neoplastic stem cells have initially been characterized in myeloid leukemias where NOD/SCID mouse-repopulating progenitors supposedly reside within a CD34+/Lin- subset of the malignant clone. These progenitors are considered to be...
8.
Prager G, Lackner E, Krauth M, Unseld M, Poettler M, Laffer S, et al.
Mol Oncol
. 2010 Jan;
4(2):150-60.
PMID: 20106729
Cancer progression is often associated with the formation of malignant effusions. Vascular endothelial growth factor (VEGF) is a major regulator of vascular permeability and has been implicated as mediator of...
9.
Lupinek C, Roux K, Laffer S, Rauter I, Reginald K, Kneidinger M, et al.
J Immunol
. 2009 Apr;
182(8):4817-29.
PMID: 19342660
IgE is a central molecule in allergic disease. We have isolated cDNAs coding for the heavy and light chains of a murine mAb specific to human IgE and expressed a...
10.
Spok A, Gaugitsch H, Laffer S, Pauli G, Saito H, Sampson H, et al.
Int Arch Allergy Immunol
. 2005 Jun;
137(2):167-80.
PMID: 15947472
The prevalence of allergic diseases has been increasing continuously and, accordingly, there is a great desire to evaluate the allergenic potential of components in our daily environment (e.g., food). Although...