Svyatoslav Tkachenko
Overview
Explore the profile of Svyatoslav Tkachenko including associated specialties, affiliations and a list of published articles.
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16
Citations
116
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Recent Articles
1.
Zhevlakova I, Liu H, Dudiki T, Gao D, Yakubenko V, Tkachenko S, et al.
Cardiovasc Res
. 2024 Oct;
PMID: 39393814
Aims: In the context of atherosclerosis, macrophages exposed to oxidized low-density lipoprotein (oxLDL) exhibit cellular abnormalities, specifically in adhesome functions, yet the mechanisms and implications of these adhesive dysfunctions remain...
2.
Woo L, Wintruba K, Wissmann B, Tkachenko S, Kubicka E, Farber E, et al.
iScience
. 2024 Aug;
27(8):110485.
PMID: 39171295
Mammalian hearts lose their regenerative potential shortly after birth. Stimulating the proliferation of preexisting cardiomyocytes is a potential therapeutic strategy for cardiac damage. In a previous study, we identified 30...
3.
Leir S, Tkachenko S, Paranjapye A, Meckler F, Van Wettere A, Kerschner J, et al.
Mol Med
. 2024 Aug;
30(1):115.
PMID: 39112965
Background: Pancreatic fibrosis is an early diagnostic feature of the common inherited disorder cystic fibrosis (CF). Many people with CF (pwCF) are pancreatic insufficient from birth and the replacement of...
4.
Mahajan A, Hong J, Krukovets I, Shin J, Tkachenko S, Espinosa-Diez C, et al.
Front Genet
. 2024 Apr;
15:1356558.
PMID: 38660676
We previously found that the pluripotency factor OCT4 is reactivated in smooth muscle cells (SMC) in human and mouse atherosclerotic plaques and plays an atheroprotective role. Loss of OCT4 in...
5.
Shin J, Hong J, Edwards-Glenn J, Krukovets I, Tkachenko S, Adelus M, et al.
Arterioscler Thromb Vasc Biol
. 2023 Nov;
44(1):238-253.
PMID: 38031841
Background: Biological sex differences play a vital role in cardiovascular diseases, including atherosclerosis. The endothelium is a critical contributor to cardiovascular pathologies since endothelial cells (ECs) regulate vascular tone, redox...
6.
Shin J, Tkachenko S, Gomez D, Tripathi R, Owens G, Cherepanova O
Front Cardiovasc Med
. 2023 Nov;
10:1276945.
PMID: 37942066
Introduction: There is growing evidence that smooth muscle cell () phenotypic transitions play critical roles during normal developmental and tissue recovery processes and in pathological conditions such as atherosclerosis. However,...
7.
Gole S, Tkachenko S, Masannat T, Baylis R, Cherepanova O
Cells
. 2022 Oct;
11(19).
PMID: 36230908
Despite many decades of research, complications of atherosclerosis resulting from the rupture or erosion of unstable plaques remain the leading cause of death worldwide. Advances in cellular lineage tracing techniques...
8.
Tilk S, Tkachenko S, Curtis C, Petrov D, McFarland C
Elife
. 2022 Sep;
11.
PMID: 36047771
Cancer genomes exhibit surprisingly weak signatures of negative selection (Martincorena et al., 2017; Weghorn, 2017). This may be because selective pressures are relaxed or because genome-wide linkage prevents deleterious mutations...
9.
Harris A, Esparza S, Azimi M, Cornelison R, Azar F, Llaneza D, et al.
Front Oncol
. 2022 Apr;
12:801764.
PMID: 35372032
Chemotherapy has been used to inhibit cancer growth for decades, but emerging evidence shows it can affect the tumor stroma, unintentionally promoting cancer malignancy. After treatment of primary tumors, remaining...
10.
Young A, Bradley L, Farrar E, Bilcheck H, Tkachenko S, Saucerman J, et al.
Circ Res
. 2022 Apr;
130(9):1345-1361.
PMID: 35369706
Background: DYRK1a (dual-specificity tyrosine phosphorylation-regulated kinase 1a) contributes to the control of cycling cells, including cardiomyocytes. However, the effects of inhibition of DYRK1a on cardiac function and cycling cardiomyocytes after...