Sverker Jern
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Explore the profile of Sverker Jern including associated specialties, affiliations and a list of published articles.
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50
Citations
935
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Recent Articles
1.
Mossberg K, Olausson J, Fryk E, Jern S, Jansson P, Brogren H
PLoS One
. 2022 Aug;
17(8):e0267833.
PMID: 36044519
Background: The main inhibitor of the fibrinolytic system, Plasminogen Activator Inhibitor -1 (PAI-1), irreversibly binds tissue-type Plasminogen Activator (t-PA) and thereby inhibits the protective action of tPA against thrombus formation....
2.
Glise Sandblad K, Rosengren A, Sorbo J, Jern S, Hansson P
Res Pract Thromb Haemost
. 2022 Jun;
6(4):e12714.
PMID: 35677029
Background: Knowledge on differences in patients who present with deep vein thrombosis (DVT) and those with pulmonary embolism (PE) is incomplete. Objective: To determine comorbidities and temporary provoking factors in...
3.
Glise L, Larsson P, Jern S, Boren J, Levin M, Ny T, et al.
Thromb Haemost
. 2019 Jan;
119(2):223-233.
PMID: 30602198
Endothelial expression of tissue-type plasminogen activator (t-PA) is crucial for maintaining an adequate endogenous fibrinolysis. It is unknown how endothelial t-PA expression and fibrinolysis are affected by blood flow in...
4.
Magnusson M, Larsson P, Lu E, Bergh N, Caren H, Jern S
Epigenetics
. 2016 Jun;
11(8):614-24.
PMID: 27302749
Epigenetics, including DNA methylation, is one way for a cell to respond to the surrounding environment. Traditionally, DNA methylation has been perceived as a quite stable modification; however, lately, there...
5.
Mossberg K, Svensson P, Gidlof O, Erlinge D, Jern S, Brogren H
Platelets
. 2016 May;
27(8):729-734.
PMID: 27232341
The mRNA of human platelets has been extensively studied and it is generally appreciated that platelets contain mRNA transcripts derived from the megakaryocytes, and they have the ability to translate...
6.
Ulfhammer E, Larsson P, Magnusson M, Karlsson L, Bergh N, Jern S
Int J Vasc Med
. 2016 Mar;
2016:7928681.
PMID: 26966581
Objective. Endothelial tissue-type plasminogen activator (t-PA) release is a pivotal response to protect the circulation from occluding thrombosis. We have shown that the t-PA gene is epigenetically regulated and greatly...
7.
Magnusson M, Lu E, Larsson P, Ulfhammer E, Bergh N, Caren H, et al.
PLoS One
. 2015 Oct;
10(10):e0141805.
PMID: 26509603
Tissue-type plasminogen activator (t-PA), which is synthesized in the endothelial cells lining the blood vessel walls, is a key player in the fibrinolytic system protecting the circulation against occluding thrombus...
8.
Svennerholm K, Haney M, Biber B, Ulfhammer E, Saluveer O, Larsson P, et al.
PLoS One
. 2015 May;
10(5):e0128283.
PMID: 25955488
No abstract available.
9.
Svennerholm K, Haney M, Biber B, Ulfhammer E, Saluveer O, Larsson P, et al.
PLoS One
. 2015 Mar;
10(3):e0121196.
PMID: 25807501
Unlabelled: The expression of the tissue plasminogen activator (t-PA) gene appears to be under epigenetic control and can be affected by histone deacetylation inhibition. The study aimed to test if...
10.
Saluveer O, Larsson P, Ridderstrale W, Hrafnkelsdottir T, Jern S, Bergh N
PLoS One
. 2014 Oct;
9(10):e107582.
PMID: 25295869
Aims: The aim of the study was to test if pharmacological intervention by valproic acid (VPA) treatment can modulate the fibrinolytic system in man, by means of increased acute release...