Sven Hendrix
Overview
Explore the profile of Sven Hendrix including associated specialties, affiliations and a list of published articles.
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69
Citations
1420
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Recent Articles
11.
Van Broeckhoven J, Sommer D, Dooley D, Hendrix S, Franssen A
Brain
. 2021 Jul;
144(10):2933-2945.
PMID: 34244729
After spinal cord injury, macrophages can exert either beneficial or detrimental effects depending on their phenotype. Aside from their critical role in inflammatory responses, macrophages are also specialized in the...
12.
Aguilera-Lizarraga J, Florens M, Viola M, Jain P, Decraecker L, Appeltans I, et al.
Nature
. 2021 Jan;
590(7844):151-156.
PMID: 33442055
Up to 20% of people worldwide develop gastrointestinal symptoms following a meal, leading to decreased quality of life, substantial morbidity and high medical costs. Although the interest of both the...
13.
Quarta A, Meese T, Pieters Z, Van Breedam E, Le Blon D, Van Broeckhoven J, et al.
Glia
. 2020 Sep;
69(2):326-345.
PMID: 32865285
Cellular models of induced pluripotent stem cell (iPSC)-derived microglia and macrophages are an emerging toolbox to investigate neuroinflammation in vitro. We previously demonstrated that murine iPSC-microglia and iPSC-macrophages display phenotypical...
14.
Grajchen E, Wouters E, van de Haterd B, Haidar M, Hardonniere K, Dierckx T, et al.
J Neuroinflammation
. 2020 Jul;
17(1):224.
PMID: 32718316
Background: The presence of foamy macrophages and microglia containing intracellular myelin remnants is a pathological hallmark of neurodegenerative disorders such as multiple sclerosis (MS). Despite the importance of myelin internalization...
15.
Hendrix S, Sanchez S, Ventriglia E, Lemmens S
Int J Mol Sci
. 2020 Jul;
21(12).
PMID: 32630606
Pan-histone deacetylase (HDAC) inhibition with valproic acid (VPA) has beneficial effects after spinal cord injury (SCI), although with side effects. We focused on specific HDAC8 inhibition, because it is known...
16.
Lemmens S, Nelissen S, Dooley D, Geurts N, Peters E, Hendrix S
J Neurotrauma
. 2019 Jun;
37(3):564-571.
PMID: 31210094
A mounting body of evidence suggests that stress plays a major role in the injury progression after spinal cord injury (SCI). Injury activates the stress systems; this in turn may...
17.
Sommer D, Corstjens I, Sanchez S, Dooley D, Lemmens S, Van Broeckhoven J, et al.
Brain Behav Immun
. 2019 Mar;
80:129-145.
PMID: 30851378
A disintegrin and metalloproteinase 17 (ADAM17) is the major sheddase involved in the cleavage of a plethora of cytokines, cytokine receptors and growth factors, thereby playing a substantial role in...
18.
Vangansewinkel T, Lemmens S, Geurts N, Quanten K, Dooley D, Pejler G, et al.
Sci Rep
. 2019 Mar;
9(1):3715.
PMID: 30842526
Spinal cord injury (SCI) triggers the formation of a glial and fibrotic scar, which creates a major barrier for neuroregenerative processes. Previous findings indicate that mast cells (MCs) protect the...
19.
Dudeck A, Koberle M, Goldmann O, Meyer N, Dudeck J, Lemmens S, et al.
J Allergy Clin Immunol
. 2018 Nov;
144(4S):S4-S18.
PMID: 30468774
Mast cells (MCs), which are well known for their effector functions in T2-skewed allergic and also autoimmune inflammation, have become increasingly acknowledged for their role in protection of health. It...
20.
Sanchez S, Lemmens S, Baeten P, Sommer D, Dooley D, Hendrix S, et al.
Exp Neurobiol
. 2018 Nov;
27(5):437-452.
PMID: 30429652
After spinal cord injury (SCI), monocyte derived macrophages play a detrimental role. Histone deacetylases (HDACs) are central epigenetic regulators of macrophage-polarization. We hypothesized that HDAC3 inhibition suppresses the pro-inflammatory macrophage...