Sven Gobel
Overview
Explore the profile of Sven Gobel including associated specialties, affiliations and a list of published articles.
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Articles
6
Citations
23
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Recent Articles
1.
Gobel S, Kazemi O, Ma J, Jordan I, Sandig V, Paulissen J, et al.
Vaccines (Basel)
. 2024 Jul;
12(7).
PMID: 39066393
The live-attenuated yellow fever 17D strain is a potent vaccine and viral vector. Its manufacture is based on embryonated chicken eggs or adherent Vero cells. Both processes are unsuitable for...
2.
Gobel S, Pelz L, Silva C, Bruhlmann B, Hill C, Altomonte J, et al.
Appl Microbiol Biotechnol
. 2024 Feb;
108(1):240.
PMID: 38413399
Cell culture-based production of vector-based vaccines and virotherapeutics is of increasing interest. The vectors used not only retain their ability to infect cells but also induce robust immune responses. Using...
3.
Gobel S, Jaen K, Fernandes R, Reiter M, Altomonte J, Reichl U, et al.
Biotechnol Bioeng
. 2023 Aug;
120(11):3335-3346.
PMID: 37584190
The development of efficient processes for the production of oncolytic viruses (OV) plays a crucial role regarding the clinical success of virotherapy. Although many different OV platforms are currently under...
4.
Gobel S, Jaen K, Dorn M, Neumeyer V, Jordan I, Sandig V, et al.
Biotechnol Bioeng
. 2023 Feb;
120(9):2639-2657.
PMID: 36779302
We present a proof-of-concept study for production of a recombinant vesicular stomatitis virus (rVSV)-based fusogenic oncolytic virus (OV), rVSV-Newcastle disease virus (NDV), at high cell densities (HCD). Based on comprehensive...
5.
Gobel S, Kortum F, Chavez K, Jordan I, Sandig V, Reichl U, et al.
Appl Microbiol Biotechnol
. 2022 Jun;
106(13-16):4945-4961.
PMID: 35767011
Oncolytic viruses (OVs) represent a novel class of immunotherapeutics under development for the treatment of cancers. OVs that express a cognate or transgenic fusion protein is particularly promising as their...
6.
Granicher G, Babakhani M, Gobel S, Jordan I, Marichal-Gallardo P, Genzel Y, et al.
Biotechnol Bioeng
. 2021 Sep;
118(12):4720-4734.
PMID: 34506646
By integrating continuous cell cultures with continuous purification methods, process yields and product quality attributes have been improved over the last 10 years for recombinant protein production. However, for the...