Suzan Boutary
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Explore the profile of Suzan Boutary including associated specialties, affiliations and a list of published articles.
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9
Citations
97
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Recent Articles
1.
Boutary S, Khalaf G, Landesman Y, Madani M, Desmaele D, Piguet F, et al.
Int J Pharm
. 2025 Jan;
671:125234.
PMID: 39855282
Small interfering RNA (siRNA) has shown promising results for the treatment of Charcot-Marie-Tooth disease 1A (CMT1A) caused by overexpression of peripheral myelin protein (PMP22), leading to myelin dysfunction and axonal...
2.
El Chemali L, Boutary S, Liu S, Liu G, Middleton R, Banati R, et al.
Int J Mol Sci
. 2024 Jul;
25(13).
PMID: 39000434
GRT-X, which targets both the mitochondrial translocator protein (TSPO) and the Kv7.2/3 (KCNQ2/3) potassium channels, has been shown to efficiently promote recovery from cervical spine injury. In the present work,...
3.
Abi Akar E, Weill L, El Khoury M, Caradeuc C, Bertho G, Boutary S, et al.
Mol Med
. 2024 Jun;
30(1):80.
PMID: 38858657
Background: Type 2 diabetes mellitus (T2DM) is a chronic metabolic disease that commonly results from a high-calorie diet and sedentary lifestyle, leading to insulin resistance and glucose homeostasis perturbation. Physical...
4.
Caillaud M, Gobeaux F, Hemadi M, Boutary S, Guenoun P, Desmaele D, et al.
Int J Pharm
. 2021 Sep;
609:121117.
PMID: 34562556
Small interfering RNAs (siRNA) are attractive and powerful tools to inhibit the expression of a targeted gene. However, their extreme hydrophilicities combined with a negative charge and short plasma half-life...
5.
Boutary S, Caillaud M, Madani M, Vallat J, Loisel-Duwattez J, Rouyer A, et al.
Commun Biol
. 2021 Mar;
4(1):317.
PMID: 33750896
Charcot-Marie-Tooth disease type 1 A (CMT1A) lacks an effective treatment. We provide a therapy for CMT1A, based on siRNA conjugated to squalene nanoparticles (siRNA PMP22-SQ NPs). Their administration resulted in...
6.
Boutary S, Echaniz-Laguna A, Adams D, Loisel-Duwattez J, Schumacher M, Massaad C, et al.
Transl Res
. 2020 Jul;
227:100-111.
PMID: 32693030
Charcot-Marie-Tooth (CMT) disease is the most frequent inherited neuropathy, affecting 1/1500 to 1/10000. CMT1A represents 60%-70% of all CMT and is caused by a duplication on chromosome 17p11.2 leading to...
7.
Eid S, El Massry M, Hichor M, Haddad M, Grenier J, Dia B, et al.
Diabetes
. 2019 Dec;
69(3):448-464.
PMID: 31882567
Diabetes triggers peripheral nerve alterations at a structural and functional level, collectively referred to as diabetic peripheral neuropathy (DPN). This work highlights the role of the liver X receptor (LXR)...
8.
Mroueh F, Noureldein M, Zeidan Y, Boutary S, Irani S, Eid S, et al.
FASEB J
. 2019 Oct;
33(12):14051-14066.
PMID: 31661292
Cancer was recently annexed to diabetic complications. Furthermore, recent studies suggest that cancer can increase the risk of diabetes. Consequently, diabetes and cancer share many risk factors, but the cellular...
9.
Massaad-Massade L, Boutary S, Caillaud M, Gracia C, Parola B, Gnaouiya S, et al.
Bioconjug Chem
. 2018 May;
29(6):1961-1972.
PMID: 29727181
The aim of the present study is to take advantage of the unique property of polyisoprenoid chains to adopt a compact molecular conformation and to use these natural and biocompatible...
10.
Eid S, Boutary S, Braych K, Sabra R, Massaad C, Hamdy A, et al.
Antioxid Redox Signal
. 2016 Jul;
25(13):703-719.
PMID: 27393154
Aim: Podocyte apoptosis is a critical mechanism for excessive loss of urinary albumin that eventuates in kidney fibrosis. Oxidative stress plays a critical role in hyperglycemia-induced glomerular injury. We explored...