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Susannah Elwyn

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Articles 13
Citations 396
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Recent Articles
1.
Abbey D, Conlon D, Rainville C, Elwyn S, Quiroz-Figueroa K, Billheimer J, et al.
Clin Transl Sci . 2021 Jun; 14(4):1369-1379. PMID: 34156146
Hepatocytes store triglycerides (TGs) in the form of lipid droplets (LDs), which are increased in hepatosteatosis. The regulation of hepatic LDs is poorly understood and new therapies to reduce hepatosteatosis...
2.
Abbey D, Elwyn S, Hand N, Musunuru K, Rader D
Hepatol Commun . 2020 Sep; 4(9):1316-1331. PMID: 32923835
Establishment of a physiologically relevant human hepatocyte-like cell system for translational research has been hampered by the limited availability of cell models that accurately reflect human biology and the pathophysiology...
3.
Nurnberg S, Guerraty M, Wirka R, Rao H, Pjanic M, Norton S, et al.
PLoS Genet . 2020 Jan; 16(1):e1008538. PMID: 31917787
Genome-wide association studies have identified multiple novel genomic loci associated with vascular diseases. Many of these loci are common non-coding variants that affect the expression of disease-relevant genes within coronary...
4.
Liu B, Pjanic M, Wang T, Nguyen T, Gloudemans M, Rao A, et al.
Am J Hum Genet . 2018 Aug; 103(3):377-388. PMID: 30146127
Coronary artery disease (CAD) is the leading cause of death globally. Genome-wide association studies (GWASs) have identified more than 95 independent loci that influence CAD risk, most of which reside...
5.
Cheung V, Nayak R, Wang I, Elwyn S, Cousins S, Morley M, et al.
PLoS Biol . 2010 Sep; 8(9). PMID: 20856902
Expression levels of human genes vary extensively among individuals. This variation facilitates analyses of expression levels as quantitative phenotypes in genetic studies where the entire genome can be scanned for...
6.
Coyne J, Elwyn S
Evolution . 2006 Apr; 60(2):279-91. PMID: 16610320
The desaturase-2 (desat2) locus of Drosophila melanogaster has two alleles whose frequencies vary geographically: one (the "Z" allele) is found primarily in east Africa and the Caribbean, and the other...
7.
Coyne J, Elwyn S, Rolan-Alvarez E
Evolution . 2006 Mar; 59(12):2588-601. PMID: 16526506
Many studies of speciation rely critically on estimates of sexual isolation obtained in the laboratory. Here we examine the sensitivity of sexual isolation to alterations in experimental design and mating...
8.
Moehring A, Llopart A, Elwyn S, Coyne J, Mackay T
Genetics . 2006 Mar; 173(1):225-33. PMID: 16510788
A major unresolved challenge of evolutionary biology is to determine the nature of the allelic variants of "speciation genes": those alleles whose interaction produces inviable or infertile interspecific hybrids but...
9.
Moehring A, Llopart A, Elwyn S, Coyne J, Mackay T
Genetics . 2006 Mar; 173(1):215-23. PMID: 16510787
Sexual isolating mechanisms that act before fertilization are often considered the most important genetic barriers leading to speciation in animals. While progress has been made toward understanding the genetic basis...
10.
Coyne J, Elwyn S, Kim S, Llopart A
Genet Res . 2005 Jan; 84(1):11-26. PMID: 15663255
We performed genetic analysis of hybrid sterility and of one morphological difference (sex-comb tooth number) on D. yakuba and D. santomea, the former species widespread in Africa and the latter...