Susannah E Murphy
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Explore the profile of Susannah E Murphy including associated specialties, affiliations and a list of published articles.
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51
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856
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Recent Articles
1.
Smith A, Hamilton S, Murphy S, Cowen P, Harmer C
Psychopharmacology (Berl)
. 2025 Mar;
PMID: 40087174
Rationale: The 5-HT receptor is expressed widely across the brain and is implicated in the mechanism of action of several therapeutics for mood disorders. However, there is limited and contradictory...
2.
Williams E, Taujanskaite U, Kamboj S, Murphy S, Harmer C
Neuropsychopharmacology
. 2025 Jan;
50(4):609-617.
PMID: 39825109
There is an ongoing need to identify novel pharmacological agents for the effective treatment of depression. One emerging candidate, which has demonstrated rapid-acting antidepressant effects in treatment-resistant groups, is nitrous...
3.
Colwell M, Tagomori H, Shang F, Cheng H, Wigg C, Browning M, et al.
Nat Commun
. 2024 Aug;
15(1):6617.
PMID: 39122687
The role of serotonin in human behaviour is informed by approaches which allow in vivo modification of synaptic serotonin. However, characterising the effects of increased serotonin signalling in human models...
4.
de Cates A, Harmer C, Harrison P, Cowen P, Emmanuel A, Travis S, et al.
Br J Psychiatry
. 2024 Aug;
225(3):371-378.
PMID: 39109752
Background: The serotonin 4 receptor (5-HTR) is a promising target for the treatment of depression. Highly selective 5-HTR agonists, such as prucalopride, have antidepressant-like and procognitive effects in preclinical models,...
5.
Pulcu E, Guinea C, Clemens H, Harmer C, Murphy S
iScience
. 2024 Mar;
27(3):109329.
PMID: 38482501
Affective biases can change how past events are recalled from memory. To capture mechanisms underlying affective memory formation, recall, and bias, we studied value-based decision-making (VBDM) between reward memories encoded...
6.
Smith A, Harmer C, Cowen P, Murphy S
CNS Drugs
. 2023 Jun;
37(7):571-585.
PMID: 37386328
Clinical depression is a common, debilitating and heterogenous disorder. Existing treatments for depression are inadequate for a significant minority of patients and new approaches are urgently needed. A wealth of...
7.
Waters S, De Giorgi R, Quinton A, Gillespie A, Murphy S, Cowen P, et al.
BJPsych Open
. 2023 Jun;
9(4):e110.
PMID: 37313755
Background: Evidence suggests inflammation may be a key mechanism by which psychosocial stress, including loneliness, predisposes to depression. Observational and clinical studies have suggested simvastatin, with its anti-inflammatory properties, may...
8.
de Cates A, Martens M, Wright L, Gibson D, Spitz G, Gould van Praag C, et al.
Biol Psychiatry Cogn Neurosci Neuroimaging
. 2023 Apr;
8(11):1124-1134.
PMID: 37098409
Background: Cognitive deficits are often comorbid with mood disorders and can cause significant functional impairment even after resolution of the primary mood symptoms. We do not currently have pharmacological treatments...
9.
Raslescu A, Kreicker S, Gillespie A, Berners-Lee W, Murphy S, Harmer C
Data Brief
. 2023 Jan;
46:108831.
PMID: 36591385
Experimental tasks comparing participants' performance for categorising, remembering, and recognising positive and negative words are widely used in the emotional cognitive domain. Such tasks are commonly used in experimental psychology...
10.
Colwell M, Tagomori H, Chapman S, Gillespie A, Cowen P, Harmer C, et al.
Transl Psychiatry
. 2022 Nov;
12(1):484.
PMID: 36396622
Impaired cognition is often overlooked in the clinical management of depression, despite its association with poor psychosocial functioning and reduced clinical engagement. There is an outstanding need for new treatments...