Susan K Clark
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Explore the profile of Susan K Clark including associated specialties, affiliations and a list of published articles.
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67
Citations
1077
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Recent Articles
1.
Aelvoet A, Martin I, Cockburn J, Cabalit C, Cuthill V, Spalding D, et al.
Endosc Int Open
. 2024 May;
12(5):E659-E665.
PMID: 38707599
Some patients with familial adenomatous polyposis (FAP) and extensive duodenal polyposis or cancer require total duodenectomy. Regular postoperative endoscopic surveillance of the remaining jejunum and stomach is recommended, but little...
2.
Meuser E, Chang K, Walters A, Hurley J, West H, Perry I, et al.
Mol Cancer Res
. 2024 Mar;
22(6):515-523.
PMID: 38546397
Implications: PIGA somatic mutation in duodenal tumors from patients with FAP and MAP and loss of membrane GPI-anchors may present new opportunities for understanding and intervention in duodenal tumorigenesis.
3.
Mak S, Alexander J, Clark S, Hawkins M, Cuthill V, Latchford A, et al.
Clin Transl Gastroenterol
. 2023 Oct;
15(1):e00645.
PMID: 37856205
Introduction: Adenoma multiplicity is associated with increased colorectal cancer (CRC) risk. The utility of genetic testing in patients with multiple colorectal adenomas (MCRA) remains uncertain. We evaluated the diagnostic yield...
4.
Patel R, Curtius K, Man R, Fletcher J, Cuthill V, Clark S, et al.
Endoscopy
. 2023 Feb;
55(9):836-846.
PMID: 36807005
Background: Long-term pouch surveillance outcomes for familial adenomatous polyposis (FAP) are unknown. We aimed to quantify surveillance outcomes and to determine which of selected possible predictive factors are associated with...
5.
Noble A, Durant L, Dilke S, Man R, Martin I, Patel R, et al.
Clin Transl Gastroenterol
. 2022 Mar;
13(7):e00428.
PMID: 35297393
Introduction: Familial adenomatous polyposis (FAP) is a condition caused by a constitutional pathogenic variant of the adenomatous polyposis coli gene that results in intestinal adenoma formation and colorectal cancer, necessitating...
6.
Fluctuating methylation clocks for cell lineage tracing at high temporal resolution in human tissues
Gabbutt C, Schenck R, Weisenberger D, Kimberley C, Berner A, Househam J, et al.
Nat Biotechnol
. 2022 Jan;
40(5):720-730.
PMID: 34980912
Molecular clocks that record cell ancestry mutate too slowly to measure the short-timescale dynamics of cell renewal in adult tissues. Here, we show that fluctuating DNA methylation marks can be...
7.
8.
Anele C, Martin I, McGinty Duggan P, Chauhan J, Clark S, Faiz O, et al.
Dis Colon Rectum
. 2021 Nov;
65(4):529-535.
PMID: 34775416
Background: Attenuated familial adenomatous polyposis is characterised by low number (≤100) and delayed development of colorectal adenomas. Various definitions have been used, and genotype-phenotype correlations have been suggested. Objective: We...
9.
Anele C, Xiang J, Martin I, Hawkins M, Man R, Clark S, et al.
Colorectal Dis
. 2021 Nov;
24(3):277-283.
PMID: 34741380
Aim: Total colectomy with ileorectal anastomosis (TC-IRA) is a surgical option for patients with familial adenomatous polyposis (FAP). Regular endoscopic surveillance of the rectum is recommended to prevent rectal cancer....
10.
Palles C, Martin L, Domingo E, Chegwidden L, McGuire J, Cuthill V, et al.
Fam Cancer
. 2021 May;
21(2):197-209.
PMID: 33948826
Pathogenic germline exonuclease domain (ED) variants of POLE and POLD1 cause the Mendelian dominant condition polymerase proof-reading associated polyposis (PPAP). We aimed to describe the clinical features of all PPAP...