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Suresh Venkateswaran

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Articles 37
Citations 544
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Recent Articles
1.
Kolachala V, Maddipatla S, Murthy S, Hwang Y, Dodd A, Sharma G, et al.
JCI Insight . 2025 Mar; 10(5). PMID: 40059828
Crohn's disease (CD) involves a complex intestinal microenvironment driven by chronic inflammation. While single-cell RNA sequencing has provided valuable insights into this biology, the spatial context is lost during single-cell...
2.
Dennison T, Edgar R, Payne F, Nayak K, Ross A, Cenier A, et al.
Gut . 2024 Jun; 73(9):1464-1477. PMID: 38857990
Objective: Epigenetic mechanisms, including DNA methylation (DNAm), have been proposed to play a key role in Crohn's disease (CD) pathogenesis. However, the specific cell types and pathways affected as well...
3.
Aschenbrenner D, Nassiri I, Venkateswaran S, Pandey S, Page M, Drowley L, et al.
Nat Commun . 2024 May; 15(1):4529. PMID: 38806456
Despite major advances in linking single genetic variants to single causal genes, the significance of genetic variation on transcript-level regulation of expression, transcript-specific functions, and relevance to human disease has...
4.
Kolachala V, Wei C, Venkateswaran S, Hill A, Warren V, Espinoza H, et al.
Autoimmunity . 2024 May; 57(1):2356089. PMID: 38770919
Autoimmune hepatitis (AIH) is a chronic, inflammatory liver disease of unknown aetiology which requires lifelong immunosuppression. Most therapeutic and outcome studies of AIH have been conducted predominantly in Caucasian (European...
5.
Geem D, Hercules D, Pelia R, Venkateswaran S, Griffiths A, Noe J, et al.
Clin Gastroenterol Hepatol . 2023 Oct; 22(2):368-376.e4. PMID: 37802268
Background & Aims: The evolution of complicated pediatric Crohn's disease (CD) in the era of anti-tumor necrosis factor (aTNF) therapy continues to be described. Because CD progresses from inflammatory to...
6.
Shim J, Park S, Venkateswaran S, Kumar D, Prince C, Parihar V, et al.
Blood . 2023 Aug; 142(23):1972-1984. PMID: 37624902
Hemophagocytic lymphohistiocytosis (HLH) is characterized by hyperinflammation and multiorgan dysfunction. Infections, including the reactivation of viruses, contribute to significant disease mortality in HLH. Although T-cell and natural killer cell-driven immune...
7.
McKenna B, Dunlop A, Corwin E, Smith A, Venkateswaran S, Brennan P
Brain Behav Immun Health . 2023 Jul; 31:100651. PMID: 37449285
Recent evidence suggests that maternal childhood adversity may have an intergenerational impact, with children of adversity-exposed mothers exhibiting elevated symptoms of psychopathology. At the same time, many children demonstrate resilience...
8.
Venkateswaran S, Somineni H, Matthews J, Kilaru V, Hyams J, Denson L, et al.
Clin Epigenetics . 2023 Mar; 15(1):50. PMID: 36964596
Background: In peripheral blood, DNA methylation (DNAm) patterns in inflammatory bowel disease patients reflect inflammatory status rather than disease status. Here, we examined DNAm in diseased rectal mucosa from ulcerative...
9.
Anbazhagan M, Geem D, Venkateswaran S, Pelia R, Kolachala V, Dodd A, et al.
Stem Cells Transl Med . 2023 Mar; 12(2):112-122. PMID: 36869704
Therapy with mesenchymal stromal cells (MSCs) has shown promise in inflammatory bowel disease-leveraging their immunosuppressive and regenerative properties. However, the potential immunogenic complications of allogenic MSCs sourced from different tissues...
10.
Maddipatla S, Kolachala V, Venkateswaran S, Dodd A, Pelia R, Geem D, et al.
Inflamm Bowel Dis . 2022 Oct; 29(2):274-285. PMID: 36206201
Background: Crohn's disease is a lifelong disease characterized by chronic inflammation of the gastrointestinal tract. Defining the cellular and transcriptional composition of the mucosa at different stages of disease progression...