Suresh L Mehta
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Explore the profile of Suresh L Mehta including associated specialties, affiliations and a list of published articles.
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52
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1736
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Recent Articles
1.
Mehta S, Namous H, Vemuganti R
Neurochem Int
. 2024 Jul;
178:105802.
PMID: 38971504
We previously showed that stroke alters circular RNA (circRNA) expression profiles. Many circRNAs undergo epitranscriptomic modifications, particularly methylation of adenosine to form N-methyladenosine (mA). This modification significantly influences the circRNA...
2.
Chelluboina B, Cho T, Park J, Mehta S, Bathula S, Jeong S, et al.
Neurochem Int
. 2024 Jun;
178:105795.
PMID: 38908519
Preconditioning-induced cerebral ischemic tolerance is known to be a beneficial adaptation to protect the brain in an unavoidable event of stroke. We currently demonstrate that a short bout (6 weeks)...
3.
Chokkalla A, Arruri V, Mehta S, Vemuganti R
Transl Stroke Res
. 2024 Jun;
PMID: 38869772
N-Methyladenosine (mA) is a neuronal-enriched, reversible post-transcriptional modification that regulates RNA metabolism. The mA-modified RNAs recruit various mA-binding proteins that act as readers. Differential mA methylation patterns are implicated in...
4.
Mehta S, Arruri V, Vemuganti R
J Neurochem
. 2024 Jan;
168(10):3430-3448.
PMID: 38279529
Post-stroke neuroinflammation is pivotal in brain repair, yet persistent inflammation can aggravate ischemic brain damage and hamper recovery. Following stroke, specific molecules released from brain cells attract and activate central...
5.
Chelluboina B, Jeong S, Davis C, Mehta S, Vemuganti R
Transl Stroke Res
. 2023 Dec;
PMID: 38129636
The microRNA-21 (miR-21) levels in the brain are crucial in determining post-stroke brain damage and recovery. The miR-21 exerts neuroprotection by targeting mRNAs that translate proteins that mediate brain damage....
6.
Mehta S, Chelluboina B, Morris-Blanco K, Bathula S, Jeong S, Arruri V, et al.
J Cereb Blood Flow Metab
. 2023 Nov;
44(2):239-251.
PMID: 37933735
We previously showed that knockdown or deletion of Fos downstream transcript (FosDT; a stroke-induced brain-specific long noncoding RNA) is neuroprotective. We presently tested the therapeutic potential of FosDT siRNA in...
7.
Mehta S, Chokkalla A, Bathula S, Arruri V, Chelluboina B, Vemuganti R
Mol Ther Nucleic Acids
. 2023 Jan;
31:57-67.
PMID: 36618263
Transient focal ischemia decreased microRNA-7 (miR-7) levels, leading to derepression of its major target α-synuclein (α-Syn) that promotes secondary brain damage. Circular RNA CDR1as is known to regulate miR-7 abundance...
8.
Mehta S, Kim T, Chelluboina B, Vemuganti R
Neuromolecular Med
. 2022 Nov;
25(1):94-101.
PMID: 36447045
Post-stroke secondary brain damage is significantly influenced by the induction and accumulation of α-Synuclein (α-Syn). α-Syn-positive inclusions are often present in tauopathies and elevated tau levels and phosphorylation promotes neurodegeneration....
9.
Chokkalla A, Jeong S, Mehta S, Davis C, Morris-Blanco K, Bathula S, et al.
Stroke
. 2022 Nov;
54(1):245-254.
PMID: 36321453
Background: FTO (fat mass and obesity-associated protein) demethylates -methyladenosine (mA), which is a critical epitranscriptomic regulator of neuronal function. We previously reported that ischemic stroke induces mA hypermethylation with a...
10.
Arruri V, Chokkalla A, Jeong S, Chelluboina B, Mehta S, Veeravalli K, et al.
Neurochem Int
. 2022 Oct;
161:105432.
PMID: 36252818
We previously reported that increased expression of matrix metalloproteinase-12 (MMP-12) mediates blood-brain barrier disruption via tight junction protein degradation after focal cerebral ischemia in rats. Currently, we evaluated whether MMP-12...