Suleyman Vural
Overview
Explore the profile of Suleyman Vural including associated specialties, affiliations and a list of published articles.
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Articles
13
Citations
147
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Recent Articles
1.
Krushkal J, Vural S, Jensen T, Wright G, Zhao Y
Clin Epigenetics
. 2022 Dec;
14(1):161.
PMID: 36461044
Background: Parent of origin-specific allelic expression of imprinted genes is epigenetically controlled. In cancer, imprinted genes undergo both genomic and epigenomic alterations, including frequent copy number changes. We investigated whether...
2.
Vural S, Chang L, Yee L, Sonkin D
Sci Rep
. 2021 Aug;
11(1):17275.
PMID: 34446762
TP53 is one of the most frequently altered genes in cancer; it can be inactivated by a number of different mechanisms. NM_000546.6 (ENST00000269305.9) is by far the predominant TP53 isoform,...
3.
Song C, Su S, Huo Z, Vural S, Galvin J, Chang L
Bioinformatics
. 2021 Mar;
37(18):3026-3028.
PMID: 33714997
Summary: In this article, we introduce a hierarchical clustering and Gaussian mixture model with expectation-maximization (EM) algorithm for detecting copy number variants (CNVs) using whole exome sequencing (WES) data. The...
4.
Vural S, Palmisano A, Reinhold W, Pommier Y, Teicher B, Krushkal J
Clin Epigenetics
. 2021 Mar;
13(1):49.
PMID: 33676569
Background: Altered DNA methylation patterns play important roles in cancer development and progression. We examined whether expression levels of genes directly or indirectly involved in DNA methylation and demethylation may...
5.
Palmisano A, Vural S, Zhao Y, Sonkin D
Hum Mutat
. 2021 Feb;
42(4):342-345.
PMID: 33600011
Splice site variants may lead to transcript alterations, causing exons inclusion, exclusion, truncation, or intron retention. Interpreting the consequences of a specific splice site variant is not straightforward, especially if...
6.
Krushkal J, Silvers T, Reinhold W, Sonkin D, Vural S, Connelly J, et al.
Clin Epigenetics
. 2020 Jun;
12(1):93.
PMID: 32586373
Background: Small cell lung cancer (SCLC) is an aggressive neuroendocrine lung cancer. SCLC progression and treatment resistance involve epigenetic processes. However, links between SCLC DNA methylation and drug response remain...
7.
Min D, Vural S, Krushkal J
Cancer Genet
. 2019 Aug;
237:19-38.
PMID: 31447063
Folate-mediated one-carbon metabolism is essential for growth and survival of cancer cells. We investigated whether the response of cancer cells to antitumor treatment may be partially influenced by variation in...
8.
Vural S, Simon R, Krushkal J
Hum Genomics
. 2018 Apr;
12(1):20.
PMID: 29642934
Background: The APOBEC gene family of cytidine deaminases plays important roles in DNA repair and mRNA editing. In many cancers, APOBEC3B increases the mutation load, generating clusters of closely spaced,...
9.
Chang L, Vural S, Sonkin D
Hum Mutat
. 2017 Aug;
38(11):1449-1453.
PMID: 28762582
Tumor-suppressor genes can be inactivated by several mechanisms and, in a majority of cases, both alleles need to be affected. One of the mechanisms of inactivation is due to deletions...
10.
Vural S, Wang X, Guda C
BMC Syst Biol
. 2016 Sep;
10 Suppl 3:62.
PMID: 27587275
Background: The high degree of heterogeneity observed in breast cancers makes it very difficult to classify the cancer patients into distinct clinical subgroups and consequently limits the ability to devise...