Sujatha Krishnakumar
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Explore the profile of Sujatha Krishnakumar including associated specialties, affiliations and a list of published articles.
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16
Citations
563
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0
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Recent Articles
1.
Horn D, Mindrinos M, Anderson K, Krishnakumar S, Wang C, Li M, et al.
Ann Surg
. 2020 Oct;
275(1):203-207.
PMID: 33064392
Objective: Determine whether variation in the HLA region is associated with the development of post-traumatic sepsis and septic shock. Background: Sepsis-related deaths remain a major source of mortality after traumatic...
2.
Raghavan M, Yarzabek B, Zaitouna A, Krishnakumar S, Ramon D
Hum Immunol
. 2019 Feb;
80(4):221-227.
PMID: 30735755
HLA class I molecules are highly polymorphic cell surface proteins that trigger immune responses by CD8 T cells and natural killer (NK) cells. Most humans express six different HLA class...
3.
Thorstenson Y, Creary L, Huang H, Rozot V, Nguyen T, Babrzadeh F, et al.
Hum Immunol
. 2018 Sep;
79(12):839-847.
PMID: 30240896
The development of next-generation sequencing (NGS) methods for HLA genotyping has already had an impact on the scope and precision of HLA research. In this study, allelic resolution HLA typing...
4.
Yarzabek B, Zaitouna A, Olson E, Silva G, Geng J, Geretz A, et al.
Elife
. 2018 Jul;
7.
PMID: 29989547
The highly polymorphic human leukocyte antigen (HLA) class I molecules present peptide antigens to CD8 T cells, inducing immunity against infections and cancers. Quality control mediated by peptide loading complex...
5.
Geng J, Altman J, Krishnakumar S, Raghavan M
Elife
. 2018 May;
7.
PMID: 29741477
When complexed with antigenic peptides, human leukocyte antigen (HLA) class I (HLA-I) molecules initiate CD8 T cell responses via interaction with the T cell receptor (TCR) and co-receptor CD8. Peptides...
6.
Deng G, Krishnakumar S, Powell A, Zhang H, Mindrinos M, Telli M, et al.
BMC Cancer
. 2014 Jun;
14:456.
PMID: 24947048
Background: Therapeutic decisions in cancer are generally guided by molecular biomarkers or, for some newer therapeutics, primary tumor genotype. However, because biomarkers or genotypes may change as new metastases emerge,...
7.
Xu W, Krishnakumar S, Miranda M, Jensen M, Fukushima M, Palm C, et al.
Appl Environ Microbiol
. 2014 May;
80(14):4153-61.
PMID: 24795371
The vast majority of microscopic life on earth consists of microbes that do not grow in laboratory culture. To profile the microbial diversity in environmental and clinical samples, we have...
8.
Zhang H, Cohen A, Krishnakumar S, Wapnir I, Veeriah S, Deng G, et al.
Breast Cancer Res
. 2014 Apr;
16(2):R36.
PMID: 24708766
Introduction: Triple-negative breast cancer (TNBC) is aggressive and lacks targeted therapies. Phosphatidylinositide 3-kinase (PI3K)/mammalian target of rapamycin (mTOR) pathways are frequently activated in TNBC patient tumors at the genome, gene...
9.
Wang C, Krishnakumar S, Wilhelmy J, Babrzadeh F, Stepanyan L, Su L, et al.
Proc Natl Acad Sci U S A
. 2012 May;
109(22):8676-81.
PMID: 22589303
Human leukocyte antigen (HLA) genes are the most polymorphic in the human genome. They play a pivotal role in the immune response and have been implicated in numerous human pathologies,...
10.
Shen P, Wang W, Krishnakumar S, Palm C, Chi A, Enns G, et al.
Proc Natl Acad Sci U S A
. 2011 Apr;
108(16):6549-54.
PMID: 21467225
The accurate and complete selection of candidate genomic regions from a DNA sample before sequencing is critical in molecular diagnostics. Several recently developed technologies await substantial improvements in performance, cost,...