Sudhir Thakurela
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Explore the profile of Sudhir Thakurela including associated specialties, affiliations and a list of published articles.
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18
Citations
612
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Recent Articles
1.
Chen S, Shcherbina A, Schafer S, Mattingly Z, Ramesh J, Narayanan C, et al.
bioRxiv
. 2025 Feb;
PMID: 39975145
Autistic individuals with disproportionate megalencephaly (ASD-DM), characterized by enlarged brains relative to body height, have higher rates of intellectual disability and face more severe cognitive challenges than autistic children with...
2.
Ajay A, Zhao L, Vig S, Fujiwara M, Thakurela S, Jadhav S, et al.
Cell Rep
. 2022 Mar;
38(10):110473.
PMID: 35263586
Signal transduction and activator of transcription 3 (STAT3) is a key transcription factor implicated in the pathogenesis of kidney fibrosis. Although Stat3 deletion in tubular epithelial cells is known to...
3.
Tripathy A, Thakurela S, Sahu M, Uthansingh K, Singh A, Narayan J, et al.
Genes Cancer
. 2020 Jun;
11(1-2):66-82.
PMID: 32577158
Backgrounds And Aims: Hepatocellular Carcinoma (HCC) is the leading cause of cancer-related mortality across the world. Non-viral etiological factors including obesity and metabolic syndrome have now become prevalent cause of...
4.
Thakurela S, Sindhu C, Yurkovsky E, Riemenschneider C, Smith Z, Nachman I, et al.
Nat Commun
. 2019 Oct;
10(1):4444.
PMID: 31570708
Ectopic transcription factor expression enables reprogramming of somatic cells to pluripotency, albeit with generally low efficiency. Despite steady progress in the field, the exact molecular mechanisms that coordinate this remarkable...
5.
Tripathy A, Thakurela S, Sahu M, Uthanasingh K, Behera M, Ajay A, et al.
PLoS One
. 2018 Dec;
13(12):e0208194.
PMID: 30513115
Background: Hepatocellular carcinoma (HCC) is leading cause of cancer-related mortality and is categorized among the most common malignancies around the world. It is a heterogeneous tumor, which shows significant degree...
6.
Stage-Specific Transcription Factors Drive Astrogliogenesis by Remodeling Gene Regulatory Landscapes
Tiwari N, Pataskar A, Peron S, Thakurela S, Sahu S, Figueres-Onate M, et al.
Cell Stem Cell
. 2018 Oct;
23(4):557-571.e8.
PMID: 30290178
A broad molecular framework of how neural stem cells are specified toward astrocyte fate during brain development has proven elusive. Here we perform comprehensive and integrated transcriptomic and epigenomic analyses...
7.
Donaghey J, Thakurela S, Charlton J, Chen J, Smith Z, Gu H, et al.
Nat Genet
. 2018 Jan;
50(2):250-258.
PMID: 29358654
Transcription factors (TFs) direct developmental transitions by binding to target DNA sequences, influencing gene expression and establishing complex gene-regultory networks. To systematically determine the molecular components that enable or constrain...
8.
Gezelius H, Moreno-Juan V, Mezzera C, Thakurela S, Rodriguez-Malmierca L, Pistolic J, et al.
Cereb Cortex
. 2016 Sep;
27(11):5054-5069.
PMID: 27655933
The thalamus is a central brain structure with topographically ordered long-range axonal projections that convey sensory information to the cortex via distinct nuclei. Although there is an increasing knowledge about...
9.
Thakurela S, Tiwari N, Schick S, Garding A, Ivanek R, Berninger B, et al.
Cell Discov
. 2016 Jul;
2:15045.
PMID: 27462442
Pax6 is a highly conserved transcription factor among vertebrates and is important in various aspects of the central nervous system development. However, the gene regulatory circuitry of Pax6 underlying these...
10.
Thakurela S, Garding A, Jung R, Muller C, Goebbels S, White R, et al.
Sci Rep
. 2016 May;
6:25828.
PMID: 27173133
Rapid nerve conduction in the CNS is facilitated by insulation of axons with myelin, a specialized oligodendroglial compartment distant from the cell body. Myelin is turned over and adapted throughout...