Subrahmanyam S Chirala
Overview
Explore the profile of Subrahmanyam S Chirala including associated specialties, affiliations and a list of published articles.
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6
Citations
435
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Recent Articles
1.
Mao J, DeMayo F, Li H, Abu-Elheiga L, Gu Z, Shaikenov T, et al.
Proc Natl Acad Sci U S A
. 2006 May;
103(22):8552-7.
PMID: 16717184
In animals, liver and white adipose are the main sites for the de novo fatty acid synthesis. Deletion of fatty acid synthase or acetyl-CoA carboxylase (ACC) 1 in mice resulted...
2.
Chirala S, Wakil S
Lipids
. 2005 Feb;
39(11):1045-53.
PMID: 15726818
Fatty acid synthase (FAS; EC 2.3.1.85) of animal tissues is a complex multifunctional enzyme consisting of two identical monomers. The FAS monomer (approximately 270 kDa) contains six catalytic activities and...
3.
Oh W, Abu-Elheiga L, Kordari P, Gu Z, Shaikenov T, Chirala S, et al.
Proc Natl Acad Sci U S A
. 2005 Jan;
102(5):1384-9.
PMID: 15677334
Acc2-/- mutant mice, when fed a high-fat/high-carbohydrate (HF/HC) diet, were protected against diet-induced obesity and diabetes. To investigate the role of acetyl-CoA carboxylase 2 (ACC2) in the regulation of energy...
4.
Chakravarty B, Gu Z, Chirala S, Wakil S, Quiocho F
Proc Natl Acad Sci U S A
. 2004 Oct;
101(44):15567-72.
PMID: 15507492
Human fatty acid synthase is a large homodimeric multifunctional enzyme that synthesizes palmitic acid. The unique carboxyl terminal thioesterase domain of fatty acid synthase hydrolyzes the growing fatty acid chain...
5.
Mao J, Chirala S, Wakil S
Proc Natl Acad Sci U S A
. 2003 Jun;
100(13):7515-20.
PMID: 12810950
Acetyl-CoA carboxylase 1 (ACC1) catalyzes the formation of malonyl-CoA, the C2 donor for de novo synthesis of long-chain fatty acids. We have identified 64 exons, including 7 alternatively spliced minor...
6.
Chirala S, Chang H, Matzuk M, Abu-Elheiga L, Mao J, Mahon K, et al.
Proc Natl Acad Sci U S A
. 2003 May;
100(11):6358-63.
PMID: 12738878
In animals, including humans, the source of long-chain saturated fatty acids is de novo synthesis, which is mediated by fatty acid synthase (FAS), ingested food, or both. To understand the...