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Stuart N Prince

Explore the profile of Stuart N Prince including associated specialties, affiliations and a list of published articles. Areas
Snapshot
Articles 7
Citations 96
Followers 0
Related Specialties
Molecular Biology
Science
Biochemistry
Top 10 Co-Authors
Oliver J Zaccheo
Christopher Williams
Matthew P Crump
Dellel Rezgui
A Bassim Hassan
E Yvonne Jones
Emily J Foulstone
Briony E Forbes
Andrew Bassim Hassan
Susana Frago
Published In
J Mol Biol
J Mol Endocrinol
Pharmaceutics
Mol Cancer Ther
Science
Affiliations
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Recent Articles
1.
Systemically Administered Homing Peptide Targets Dystrophic Lesions and Delivers Transforming Growth Factor-β (TGFβ) Inhibitor to Attenuate Murine Muscular Dystrophy Pathology
Iqbal A, May U, Prince S, Jarvinen T, Heydemann A
Pharmaceutics . 2021 Sep; 13(9). PMID: 34575582
Muscular dystrophy is a progressively worsening and lethal disease, where accumulation of functionality-impairing fibrosis plays a key pathogenic role. Transforming growth factor-β1 (TGFβ1) is a central signaling molecule in the...
2.
Functional evolution of IGF2:IGF2R domain 11 binding generates novel structural interactions and a specific IGF2 antagonist
Frago S, Nicholls R, Strickland M, Hughes J, Williams C, Garner L, et al.
Proc Natl Acad Sci U S A . 2016 May; 113(20):E2766-75. PMID: 27140600
Among the 15 extracellular domains of the mannose 6-phosphate/insulin-like growth factor-2 receptor (M6P/IGF2R), domain 11 has evolved a binding site for IGF2 to negatively regulate ligand bioavailability and mammalian growth....
3.
An exon splice enhancer primes IGF2:IGF2R binding site structure and function evolution
Williams C, Hoppe H, Rezgui D, Strickland M, Forbes B, Grutzner F, et al.
Science . 2012 Dec; 338(6111):1209-13. PMID: 23197533
Placental development and genomic imprinting coevolved with parental conflict over resource distribution to mammalian offspring. The imprinted genes IGF2 and IGF2R code for the growth promoter insulin-like growth factor 2...
4.
Structure and function of the human Gly1619Arg polymorphism of M6P/IGF2R domain 11 implicated in IGF2 dependent growth
Rezgui D, Williams C, Savage S, Prince S, Zaccheo O, Jones E, et al.
J Mol Endocrinol . 2009 Feb; 42(4):341-56. PMID: 19208780
The mannose 6-phosphate/IGF 2 receptor (IGF2R) is comprised of 15 extra-cellular domains that bind IGF2 and mannose 6-phosphate ligands. IGF2R transports ligands from the Golgi to the pre-lysosomal compartment and...
5.
Structural insights into the interaction of insulin-like growth factor 2 with IGF2R domain 11
Williams C, Rezgui D, Prince S, Zaccheo O, Foulstone E, Forbes B, et al.
Structure . 2007 Sep; 15(9):1065-78. PMID: 17850746
The insulin-like growth factor II/mannose-6-phosphate receptor (IGF2R) mediates trafficking of mannose-6-phosphate (M6P)-containing proteins and the mitogenic hormone IGF2. IGF2R also plays an important role as a tumor suppressor, as mutation...
6.
Functional evaluation of novel soluble insulin-like growth factor (IGF)-II-specific ligand traps based on modified domain 11 of the human IGF2 receptor
Prince S, Foulstone E, Zaccheo O, Williams C, Hassan A
Mol Cancer Ther . 2007 Feb; 6(2):607-17. PMID: 17308058
Ligands transported by the mannose 6-phosphate/insulin-like growth factor (IGF)-II receptor (IGF2R) include IGF-II- and mannose 6-phosphate-modified proteins. Increased extracellular supply of IGF-II, either secondary to loss of the clearance function...
7.
Kinetics of insulin-like growth factor II (IGF-II) interaction with domain 11 of the human IGF-II/mannose 6-phosphate receptor: function of CD and AB loop solvent-exposed residues
Zaccheo O, Prince S, Miller D, Williams C, Kemp C, Brown J, et al.
J Mol Biol . 2006 Apr; 359(2):403-21. PMID: 16631789
Ligands of the IGF-II/mannose 6-phosphate receptor (IGF2R) include IGF-II and mannose 6-phosphate modified proteins. Disruption of the negative regulatory effects of IGF2R on IGF-II-induced growth can lead to embryonic lethality...