Stuart J Hesketh
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Explore the profile of Stuart J Hesketh including associated specialties, affiliations and a list of published articles.
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Recent Articles
1.
Hesketh S, Esser K
Free Radic Biol Med
. 2024 Aug;
224():78-87.
PMID: 39168419
Exercise physiology and circadian biology are distinct and long-standing fields. Recently they have seen increased integration, largely due to the discovery of the molecular components of the circadian clock and...
2.
Viggars M, Berko H, Hesketh S, Wolff C, Gutierrez-Monreal M, Martin R, et al.
Mol Metab
. 2024 Jul;
86:101980.
PMID: 38950777
Objective: In this investigation, we addressed the contribution of the core circadian clock factor, BMAL1, in skeletal muscle to both acute transcriptional responses to exercise and transcriptional remodeling in response...
3.
Hesketh S
Sports Med Health Sci
. 2024 Mar;
6(1):1-15.
PMID: 38463663
Muscle atrophy exacerbates disease outcomes and increases mortality, whereas the preservation of skeletal muscle mass and function play pivotal roles in ensuring long-term health and overall quality-of-life. Muscle atrophy represents...
4.
Viggars M, Berko H, Hesketh S, Wolff C, Gutierrez-Monreal M, Martin R, et al.
bioRxiv
. 2023 Oct;
PMID: 37905004
Objectives: In this investigation, we addressed the contribution of the core circadian clock factor, BMAL1, in skeletal muscle to both acute transcriptional responses to exercise and transcriptional remodelling in response...
5.
Hesketh S, Sexton C, Wolff C, Viggars M, Esser K
bioRxiv
. 2023 Oct;
PMID: 37781623
Time-of-day differences in acute exercise performance in mice are well established with late active phase (afternoon) runners exhibiting significantly greater endurance performance compared to early active phase (morning) runners. In...
6.
Wolff C, Gutierrez-Monreal M, Meng L, Zhang X, Douma L, Costello H, et al.
Cell Rep
. 2023 Jan;
42(1):111982.
PMID: 36640301
Cellular circadian clocks direct a daily transcriptional program that supports homeostasis and resilience. Emerging evidence has demonstrated age-associated changes in circadian functions. To define age-dependent changes at the systems level,...
7.
Hesketh S, Stansfield B, Stead C, Burniston J
Expert Rev Proteomics
. 2021 Jan;
17(11-12):813-825.
PMID: 33470862
Introduction: Exercise offers protection from non-communicable diseases and extends healthspan by offsetting natural physiological declines that occur in older age. Striated muscle is the largest bodily organ; it underpins the...
8.
Douglas C, Hesketh S, Esser K
Physiology (Bethesda)
. 2020 Dec;
36(1):44-51.
PMID: 33325817
For more than 20 years, physiologists have observed a morning-to-evening increase in human muscle strength. Recent data suggest that time-of-day differences are the result of intrinsic, nonneural, muscle factors. We...
9.
Hesketh S, Sutherland H, Lisboa P, Jarvis J, Burniston J
FASEB J
. 2020 Jun;
34(8):10398-10417.
PMID: 32598083
Muscle adaptations to exercise are underpinned by alterations to the abundance of individual proteins, which may occur through a change either to the synthesis or degradation of each protein. We...
10.
Stead C, Hesketh S, Bennett S, Sutherland H, Jarvis J, Lisboa P, et al.
Proteomes
. 2020 May;
8(2).
PMID: 32403418
Differences in the protein composition of fast- and slow-twitch muscle may be maintained by different rates of protein turnover. We investigated protein turnover rates in slow-twitch soleus and fast-twitch plantaris...