Steven W Magennis
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Explore the profile of Steven W Magennis including associated specialties, affiliations and a list of published articles.
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42
Citations
364
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Recent Articles
11.
Samaan G, Wyllie M, Cizmic J, Needham L, Nobis D, Ngo K, et al.
Chem Sci
. 2021 Jun;
12(7):2623-2628.
PMID: 34164030
Fluorescent nucleobase surrogates capable of Watson-Crick hydrogen bonding are essential probes of nucleic acid structure and dynamics, but their limited brightness and short absorption and emission wavelengths have rendered them...
12.
Hu T, Morten M, Magennis S
Nat Commun
. 2021 Jan;
12(1):204.
PMID: 33420051
Expansions of CAG/CTG trinucleotide repeats in DNA are the cause of at least 17 degenerative human disorders, including Huntington's Disease. Repeat instability is thought to occur via the formation of...
13.
Berrocal-Martin R, Sanchez-Cano C, Chiu C, Needham R, Sadler P, Magennis S
Chemistry
. 2020 Jan;
26(22):4980-4987.
PMID: 31999015
The metallation of nucleic acids is key to wide-ranging applications, from anticancer medicine to nanomaterials, yet there is a lack of understanding of the molecular-level effects of metallation. Here, we...
14.
Bell J, Harkiss A, Nobis D, Malcolm E, Knuhtsen A, Wellaway C, et al.
Chem Commun (Camb)
. 2020 Jan;
56(12):1887-1890.
PMID: 31956866
The synthesis and photophysical properties of a new class of α-amino acid bearing a rigid pyrazoloquinazoline chromophore are described. Confromational constraint of the amino acid side-chains resulted in high emission...
15.
Nobis D, Fisher R, Simmermacher M, Hopkins P, Tor Y, Jones A, et al.
J Phys Chem Lett
. 2019 Aug;
10(17):5008-5012.
PMID: 31397575
The ability to routinely detect fluorescent nucleobase analogues at the single-molecule level would create a wealth of opportunities to study nucleic acids. We report the multiphoton-induced fluorescence and single-molecule detection...
16.
Fisher R, Nobis D, Fuchtbauer A, Bood M, Grotli M, Wilhelmsson L, et al.
Phys Chem Chem Phys
. 2018 Nov;
20(45):28487-28498.
PMID: 30412214
Fluorescent nucleobase analogues (FBAs) have many desirable features in comparison to extrinsic fluorescent labels, but they are yet to find application in ultrasensitive detection. Many of the disadvantages of FBAs...
17.
Morten M, Lopez S, Steinmark I, Rafferty A, Magennis S
Nucleic Acids Res
. 2018 Oct;
46(21):11618-11626.
PMID: 30277520
From gene expression to nanotechnology, understanding and controlling DNA requires a detailed knowledge of its higher order structure and dynamics. Here we take advantage of the environment-sensitive photoisomerization of cyanine...
18.
Bood M, Fuchtbauer A, Wranne M, Ro J, Sarangamath S, El-Sagheer A, et al.
Chem Sci
. 2018 May;
9(14):3494-3502.
PMID: 29780479
Emissive base analogs are powerful tools for probing nucleic acids at the molecular level. Herein we describe the development and thorough characterization of pentacyclic adenine (pA), a versatile base analog...
19.
Venkatesh V, Berrocal-Martin R, Wedge C, Romero-Canelon I, Sanchez-Cano C, Song J, et al.
Chem Sci
. 2018 Mar;
8(12):8271-8278.
PMID: 29568475
Mitochondria generate energy but malfunction in many cancer cells, hence targeting mitochondrial metabolism is a promising approach for cancer therapy. Here we have designed cyclometallated iridium(iii) complexes, containing one TEMPO...
20.
Baltierra-Jasso L, Morten M, Magennis S
Chemphyschem
. 2018 Jan;
19(5):551-555.
PMID: 29316151
Non-enzymatic DNA strand displacement is an important mechanism in dynamic DNA nanotechnology. Here, we show that the large parameter space that is accessible by single-molecule FRET is ideal for the...