Steven R Little
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Explore the profile of Steven R Little including associated specialties, affiliations and a list of published articles.
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92
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1431
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Recent Articles
1.
Bentley E, Subick S, Doran J, Kobyra J, Balmert S, Little S
Drug Deliv Transl Res
. 2025 Mar;
PMID: 40057627
Allergic contact dermatitis (ACD), a T-cell mediated inflammatory skin condition, is prompted by multiple, subsequent exposures to contact allergens (e.g., nickel). Current treatment approaches for ACD include repeated topical application...
2.
Shehabeldin M, Kobyra J, Cho Y, Gao J, Chong R, Tabib T, et al.
J Immunol
. 2024 Oct;
213(11):1635-1643.
PMID: 39465979
Chronic inflammatory diseases are a leading global health problem. In many of these diseases, the consistent presence of systemic low-grade inflammation induces tissue damage. This is true in conditions such...
3.
Yonet-Tanyeri N, Parker R, Falo Jr L, Little S
Pharmaceutics
. 2024 Oct;
16(10).
PMID: 39458596
Methods: Therefore, rhCCL22-loaded poly(lactic-co-glycolic) acid (PLGA) microparticles were prepared by conventional homogenization and microfluidics methods. Results: The resulting microparticles were analyzed comparatively, focusing on critical quality attributes such as microparticle...
4.
Lorentz K, Marini A, Bruk L, Gupta P, Mandal B, DiLeo M, et al.
Bioengineering (Basel)
. 2024 Sep;
11(9).
PMID: 39329689
Coronary artery disease leads to over 360,000 deaths annually in the United States, and off-the-shelf bypass graft options are currently limited and/or have high failure rates. Tissue-engineered vascular grafts (TEVGs)...
5.
Shehabeldin M, Gao J, Cho Y, Chong R, Tabib T, Li L, et al.
Proc Natl Acad Sci U S A
. 2024 Aug;
121(36):e2400528121.
PMID: 39186644
Many chronic inflammatory diseases are attributed to disturbances in host-microbe interactions, which drive immune-mediated tissue damage. Depending on the anatomic setting, a chronic inflammatory disease can exert unique local and...
6.
Naaz A, Turnquist H, Gorantla V, Little S
Adv Drug Deliv Rev
. 2024 Aug;
213:115429.
PMID: 39142608
Drug delivery strategies for local immunomodulation hold tremendous promise compared to current clinical gold-standard systemic immunosuppression as they could improve the benefit to risk ratio of life-saving or life-enhancing transplants....
7.
Bentley E, Subick S, Pezzillo M, Balmert S, Herbert A, Little S
Pharmaceutics
. 2024 Jun;
16(6).
PMID: 38931917
In the past several decades, polymeric microparticles (MPs) have emerged as viable solutions to address the limitations of standard pharmaceuticals and their corresponding delivery methods. While there are many preclinical...
8.
Acharya A, Sezginel K, Gideon H, Greene A, Lawson H, Inamdar S, et al.
J Control Release
. 2022 Oct;
352:242-255.
PMID: 36273529
Conventional drug delivery systems have been applied to a myriad of active ingredients but may be difficult to tailor for a given drug. Herein, we put forth a new strategy,...
9.
Yonet-Tanyeri N, Amer M, Balmert S, Korkmaz E, Falo Jr L, Little S
ACS Biomater Sci Eng
. 2022 Jun;
8(7):2864-2877.
PMID: 35674145
Particles synthesized from biodegradable polymers hold great potential as controlled drug delivery systems. Continuous flow platforms based on microfluidics offer attractive advantages over conventional batch-emulsification techniques for the scalable fabrication...
10.
Greene A, Shehabeldin M, Gao J, Balmert S, Ratay M, Sfeir C, et al.
Sci Rep
. 2022 Mar;
12(1):5032.
PMID: 35322204
Periodontitis (periodontal disease) is a highly prevalent disease, affecting over 65 million adults in the United States alone. Characterized by an overburden of invasive bacteria, gum inflammation and plaque buildup,...