Alpha 2.0
Login Register
» Authors » Steven Orr

Steven Orr

Explore the profile of Steven Orr including associated specialties, affiliations and a list of published articles. Areas
Snapshot
Articles 12
Citations 92
Followers 0
Related Specialties
Chemistry
General Surgery
Orthopedics
Top 10 Co-Authors
Larry H Matherly
Zhanjun Hou
Aleem Gangjee
Sudhir Raghavan
Shermaine Mitchell-Ryan
Christina George
Mike R Wilson
Adrianne Wallace
Yiqiang Wang
Christina Cherian
Published In
J Med Chem
J Hand Surg Am
JB JS Open Access
J Bone Joint Surg Am
Toxics
Affiliations
Soon will be listed here.
Recent Articles
1.
Fascial Lengthening at the Time of Surgical Release for de Quervain's Tenosynovitis to Prevent Postsurgical Tendon Subluxation
Jain N, Barr M, Miller A, DeLong M, Orr S, Benhaim P
Hand (N Y) . 2024 Jan; :15589447231218403. PMID: 38229420
Background: De Quervain's tenosynovitis is a relatively common, painful condition. Although commonly managed nonoperatively, some patients have recalcitrant disease, necessitating surgical release. Traditional surgical release for de Quervain's tenosynovitis with...
2.
Reply to "Letter Regarding 'Traumatic Nondissociative Carpal Instability: A Case Series'"
Loisel F, Orr S, Ross M, Couzens G, Leo A, Wolfe S
J Hand Surg Am . 2022 Aug; 47(8):e17. PMID: 35926977
No abstract available.
3.
Traumatic Nondissociative Carpal Instability: A Case Series
Loisel F, Orr S, Ross M, Couzens G, Leo A, Wolfe S
J Hand Surg Am . 2021 Jun; 47(3):285.e1-285.e11. PMID: 34176708
Purpose: We report 8 cases of acute or subacute unilateral nondissociative carpal instability (CIND) in the context of nondisplaced scaphoid fractures. Methods: Eight patients from 3 centers developed abnormal volar...
4.
Intermediate-Term Outcomes Following Operative and Nonoperative Management of Midshaft Clavicle Fractures in Children and Adolescents: Internal Fixation May Improve Outcomes
Swarup I, Maheshwer B, Orr S, Kehoe C, Zhang Y, Dodwell E
JB JS Open Access . 2021 Mar; 6(1). PMID: 33748645
Methods: Children and adolescents who were 10 to 18 years of age with midshaft clavicle fractures treated from 2006 to 2017 were identified through electronic picture archiving and communication system...
5.
Exposure of Larval Zebrafish to the Insecticide Propoxur Induced Developmental Delays that Correlate with Behavioral Abnormalities and Altered Expression of and
Shields J, Hales E, Ranspach L, Luo X, Orr S, Runft D, et al.
Toxics . 2019 Sep; 7(4). PMID: 31546644
Recent studies suggest that organophosphates and carbamates affect human fetal development, resulting in neurological and growth impairment. However, these studies are conflicting and the extent of adverse effects due to...
6.
An Initiative to Standardize the Identification of and Acute Response to Postoperative Lower-Extremity Neurological Deficits: Effects on Provider Knowledge, Confidence, and Communication Skills
Derman P, Iyer S, Garner M, Orr S, Felix K, Goldberg A, et al.
J Bone Joint Surg Am . 2016 Dec; 98(23):e105. PMID: 27926687
Background: Although relatively uncommon, neurological deficits following hip and knee arthroplasty can have permanent and debilitating consequences. This study was conducted to quantify the effectiveness of an educational curriculum aimed...
7.
Correction to Structure-Activity Profiles of Novel 6-Substituted Pyrrolo[2,3-d]pyrimidine Thienoyl Antifolates with Modified Amino Acids for Cellular Uptake by Folate Receptors α and β and the Proton-Coupled Folate Transporter
Golani L, George C, Zhao S, Raghavan S, Orr S, Wallace A, et al.
J Med Chem . 2016 Apr; 59(8):4032. PMID: 27082426
No abstract available.
8.
6-Substituted Pyrrolo[2,3-d]pyrimidine Thienoyl Regioisomers as Targeted Antifolates for Folate Receptor α and the Proton-Coupled Folate Transporter in Human Tumors
Wang L, Wallace A, Raghavan S, Deis S, Wilson M, Yang S, et al.
J Med Chem . 2015 Aug; 58(17):6938-59. PMID: 26317331
2-Amino-4-oxo-6-substituted-pyrrolo[2,3-d]pyrimidine antifolate thiophene regioisomers of AGF94 (4) with a thienoyl side chain and three-carbon bridge lengths [AGF150 (5) and AGF154 (7)] were synthesized as potential antitumor agents. These analogues inhibited...
9.
Novel 5-substituted pyrrolo[2,3-d]pyrimidines as dual inhibitors of glycinamide ribonucleotide formyltransferase and 5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase and as potential antitumor agents
Wang Y, Mitchell-Ryan S, Raghavan S, George C, Orr S, Hou Z, et al.
J Med Chem . 2015 Jan; 58(3):1479-93. PMID: 25602637
A new series of 5-substituted thiopheneyl pyrrolo[2,3-d]pyrimidines 6-11 with varying chain lengths (n = 1-6) were designed and synthesized as hybrids of the clinically used anticancer drug pemetrexed (PMX) and...
10.
Structure-activity profiles of novel 6-substituted pyrrolo[2,3-d]pyrimidine thienoyl antifolates with modified amino acids for cellular uptake by folate receptors α and β and the proton-coupled folate transporter
Golani L, George C, Zhao S, Raghavan S, Orr S, Wallace A, et al.
J Med Chem . 2014 Sep; 57(19):8152-66. PMID: 25234128
Structure-activity relationships for cellular uptake and inhibition of cell proliferation were studied for 2-amino-4-oxo-6-substituted pyrrolo[2,3-d]pyrimidine thienoyl antifolates in which the terminal l-glutamate of the parent structure (7) was replaced by...