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Steven N Hart

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Articles 115
Citations 5677
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Recent Articles
11.
Huang H, Hu C, Na J, Hart S, Gnanaolivu R, Abozaid M, et al.
bioRxiv . 2024 Jan; PMID: 38168194
Summary: Germline BRCA2 loss-of function (LOF) variants identified by clinical genetic testing predispose to several types of cancer. However, variants of uncertain significance (VUS) limit the clinical use of testing...
12.
Hughley R, Matejcic M, Song Z, Sheng X, Wan P, Xia L, et al.
Cancer Res Commun . 2023 Nov; 3(12):2544-2550. PMID: 38014910
Significance: These findings highlight the importance of considering rare and common variants to comprehensively assess prostate cancer risk in men of African ancestry.
13.
Hart S, Hoffman N, Gershkovich P, Christenson C, McClintock D, Miller L, et al.
J Pathol Inform . 2023 Oct; 14:100338. PMID: 37860713
In this paper, we consider the current and potential role of the latest generation of Large Language Models (LLMs) in medical informatics, particularly within the realms of clinical and anatomic...
14.
Thagaard J, Broeckx G, Page D, Jahangir C, Verbandt S, Kos Z, et al.
J Pathol . 2023 Aug; 260(5):498-513. PMID: 37608772
The clinical significance of the tumor-immune interaction in breast cancer is now established, and tumor-infiltrating lymphocytes (TILs) have emerged as predictive and prognostic biomarkers for patients with triple-negative (estrogen receptor,...
15.
Page D, Broeckx G, Jahangir C, Verbandt S, Gupta R, Thagaard J, et al.
J Pathol . 2023 Aug; 260(5):514-532. PMID: 37608771
Modern histologic imaging platforms coupled with machine learning methods have provided new opportunities to map the spatial distribution of immune cells in the tumor microenvironment. However, there exists no standardized...
16.
Gruber L, Hart S, Maher Iii L
Endocr Oncol . 2023 Jul; 3(1):e220093. PMID: 37434649
Mutations that predispose to familial pheochromocytoma and paraganglioma include inherited variants in the four genes (, , and ) encoding subunits of succinate dehydrogenase (SDH), an enzyme of the mitochondrial...
17.
Hu C, Nagaraj A, Shimelis H, Montalban G, Lee K, Huang H, et al.
Cancer Res . 2023 May; 83(15):2557-2571. PMID: 37253112
Significance: Functional analysis of the impact of a large number of missense variants on RAD51C function provides insight into RAD51C activity and information for classification of the cancer relevance of...
18.
Yadav S, Boddicker N, Na J, Polley E, Hu C, Hart S, et al.
J Clin Oncol . 2023 Jan; 41(9):1703-1713. PMID: 36623243
Purpose: To estimate the risk of contralateral breast cancer (CBC) among women with germline pathogenic variants (PVs) in , , , , and . Methods: The study population included 15,104...
19.
Patel A, Williams C, Hart S, Garcia C, Durant T, Cornish T, et al.
J Appl Lab Med . 2023 Jan; 8(1):145-161. PMID: 36610432
Background: Network-connected medical devices have rapidly proliferated in the wake of recent global catalysts, leaving clinical laboratories and healthcare organizations vulnerable to malicious actors seeking to ransom sensitive healthcare information....
20.
Dixon-Suen S, Lewis S, Martin R, English D, Boyle T, Giles G, et al.
Br J Sports Med . 2022 Nov; 56(20):1157-1170. PMID: 36328784
Objectives: Physical inactivity and sedentary behaviour are associated with higher breast cancer risk in observational studies, but ascribing causality is difficult. Mendelian randomisation (MR) assesses causality by simulating randomised trial...