Steven Mennerick
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Explore the profile of Steven Mennerick including associated specialties, affiliations and a list of published articles.
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125
Citations
4249
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Recent Articles
1.
Lu X, Shu H, Lambert P, Benz A, Zorumski C, Mennerick S
J Neurophysiol
. 2025 Feb;
PMID: 40013665
In medial prefrontal cortex (mPFC), fast-spiking parvalbumin (PV) interneurons regulate excitability and microcircuit oscillatory activity important for cognition. Although PV interneurons inhibit pyramidal neurons, they themselves express δ subunits of...
2.
Izumi Y, ODell K, Mennerick S, Zorumski C
Sci Rep
. 2025 Feb;
15(1):6149.
PMID: 39979396
Neuroinflammation is an increasingly important target for therapeutics in neuropsychiatry and contributes to cognitive dysfunction, disability and death across a range of illnesses. We previously found that acute effects of...
3.
Kumar A, Qian M, Xu Y, Benz A, Covey D, Zorumski C, et al.
bioRxiv
. 2025 Feb;
PMID: 39896603
Background And Purpose: Neurosteroids modulate neuronal function and are promising therapeutic agents for neuropsychiatric disorders. Neurosteroid analogues are approved for treating postpartum depression and are of interest in other disorders....
4.
Qian M, Xu Y, Shu H, Chen Z, Wang L, Zorumski C, et al.
RSC Adv
. 2024 Nov;
14(49):36352-36369.
PMID: 39539530
The endogenous neurosteroids dehydroepiandrosterone sulfate (DHEAS) and pregnenolone sulfate (PS) are allosteric modulators of γ-aminobutyric acid type A (GABA) and -methyl-d-aspartate (NMDA) type glutamate receptors. Analogues of these endogenous steroid...
5.
Conway C, Palanca B, Zeffiro T, Gott B, Brown F, de Leon V, et al.
medRxiv
. 2024 Aug;
PMID: 39185528
While nitrous oxide (NO) has demonstrated antidepressant properties in treatment-resistant major depression (TRD), little is known about neural mechanisms mediating these effects. Employing serial resting-state functional magnetic resonance imaging (rs-fMRI),...
6.
Granados-Fuentes D, Lambert P, Simon T, Mennerick S, Herzog E
Proc Natl Acad Sci U S A
. 2024 Jul;
121(31):e2400339121.
PMID: 39047036
The mammalian circadian clock located in the suprachiasmatic nucleus (SCN) produces robust daily rhythms including rest-wake. SCN neurons synthesize and respond to γ-aminobutyric acid (GABA), but its role remains unresolved....
7.
Lu X, Shu H, Lambert P, Benz A, Zorumski C, Mennerick S
bioRxiv
. 2024 Jun;
PMID: 38915641
Significance Statement: By selectively deleting δ-containing GABAA receptors in PV interneurons, we demonstrate the importance of these receptors on PV interneuron excitability, synaptic inhibition of pyramidal neurons, and circuit function.
8.
Lambert P, Salvatore S, Lu X, Shu H, Benz A, Rensing N, et al.
bioRxiv
. 2024 Apr;
PMID: 38585911
Significance Statement: The impact on cortical EEG of inhibition on PV+ neurons was studied by deleting a GABA receptor subunit selectively from these neurons. We discovered unexpected changes at low...
9.
Shu H, Ziolkowski L, Salvatore S, Benz A, Wozniak D, Yuede C, et al.
Biomolecules
. 2024 Mar;
14(3).
PMID: 38540675
Brain cholesterol metabolic products include neurosteroids and oxysterols, which play important roles in cellular physiology. In neurons, the cholesterol oxidation product, 24S-hydroxycholesterol (24S-HC), is a regulator of signaling and transcription....
10.
Salvatore S, Lambert P, Benz A, Rensing N, Wong M, Zorumski C, et al.
J Neurophysiol
. 2024 Feb;
131(3):529-540.
PMID: 38323322
Cortical electroencephalograms (EEGs) may help understanding of neuropsychiatric illness and new treatment mechanisms. The aperiodic component (1/) of EEG power spectra is often treated as noise, but recent studies suggest...