Steven M Shapiro
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Explore the profile of Steven M Shapiro including associated specialties, affiliations and a list of published articles.
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39
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736
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Recent Articles
11.
Wennberg R, Watchko J, Shapiro S
Curr Pediatr Rev
. 2017 Aug;
13(3):210-219.
PMID: 28847288
Background: Kernicterus is a common cause of death and morbidity in many Low- Middle-income Countries (LMICs) and still occurs in affluent nations. In either case, the immediate cause is delayed...
12.
Le Pichon J, Riordan S, Watchko J, Shapiro S
Curr Pediatr Rev
. 2017 Aug;
13(3):199-209.
PMID: 28814249
Background: Despite its lengthy history, the study of jaundice, hyperbilirubinemia and kernicterus suffers from a lack of clarity and consistency in the key terms used to describe both the clinical...
13.
Yang F, Riordan S, Winter M, Gan L, Smith P, Vivian J, et al.
Cell Transplant
. 2017 Feb;
26(4):605-611.
PMID: 28155818
High levels of bilirubin in infants can cause kernicterus, which includes basal ganglia damage and dystonia. Stem cell transplantation may be an effective treatment for this disease. In this study,...
14.
Riordan S, Bittel D, Le Pichon J, Gazzin S, Tiribelli C, Watchko J, et al.
Front Neurosci
. 2016 Sep;
10:376.
PMID: 27587993
Genetic-based susceptibility to bilirubin neurotoxicity and chronic bilirubin encephalopathy (kernicterus) is still poorly understood. Neonatal jaundice affects 60-80% of newborns, and considerable effort goes into preventing this relatively benign condition...
15.
Gazzin S, Vitek L, Watchko J, Shapiro S, Tiribelli C
Trends Mol Med
. 2016 Aug;
22(9):758-768.
PMID: 27515064
Unconjugated bilirubin (UCB) is known to be one of the most potent endogenous antioxidant substances. While hyperbilirubinemia has long been recognized as an ominous sign of liver dysfunction, recent data...
16.
Greco C, Arnolda G, Boo N, Iskander I, Okolo A, Rohsiswatmo R, et al.
Neonatology
. 2016 May;
110(3):172-80.
PMID: 27172942
Severe neonatal hyperbilirubinemia, defined as total serum bilirubin (TSB) ≥20 mg/dl, is associated with a higher risk of permanent neurological sequelae and death. Jaundice can and should be promptly diagnosed...
17.
Stanford J, Shuler J, Fowler S, Stanford K, Ma D, Bittel D, et al.
Pediatr Res
. 2014 Dec;
77(3):434-9.
PMID: 25518009
Background: Neonatal jaundice resulting from elevated unconjugated bilirubin occurs in 60-80% of newborn infants. Although mild jaundice is generally considered harmless, little is known about its long-term consequences. Recent studies...
18.
Thornton K, Nyp M, Aplenc L, Jones G, Carpenter S, Guest E, et al.
Case Rep Pediatr
. 2013 Nov;
2013:284029.
PMID: 24288641
We present an unusual case of hyperbilirubinemia with rapid early progression leading to bilirubin encephalopathy in a term neonate. Despite early recognition and intervention, the total serum bilirubin reached a...
19.
Schreuder A, Rice A, Vanikova J, Vitek L, Shapiro S, Verkade H
Liver Int
. 2013 Jun;
33(10):1557-65.
PMID: 23742048
Background: Free bilirubin (Bf), the unbound fraction of unconjugated bilirubin (UCB), can induce neurotoxicity, including impairment of the auditory system, which can be assessed by brainstem auditory evoked potentials (BAEPs)....
20.
Baron M, Chaniary K, Rice A, Shapiro S
Front Syst Neurosci
. 2011 Sep;
5:67.
PMID: 21941468
Classical rate-based pathway models are invaluable for conceptualizing direct/indirect basal ganglia pathways, but cannot account for many aspects of normal and abnormal motor control. To better understand the contribution of...