Steven L Cockrill
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Explore the profile of Steven L Cockrill including associated specialties, affiliations and a list of published articles.
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Articles
12
Citations
260
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Recent Articles
1.
Zhang B, Towers E, Poppe L, Cockrill S
J Pharm Sci
. 2011 Jun;
100(11):4607-16.
PMID: 21647888
We report the identification and characterization of a novel degradation product associated with PEGylation of a recombinant protein. After several months of storage at 2°C-8°C, an unexpected increase was observed...
2.
Prien J, Prater B, Cockrill S
Glycobiology
. 2010 Jan;
20(5):629-47.
PMID: 20110246
Regulatory agencies' expectations for biotherapeutic approval are becoming more stringent with regard to product characterization, where minor species as low as 0.1% of a given profile are typically identified. The...
3.
Prien J, Prater B, Qin Q, Cockrill S
Anal Chem
. 2010 Jan;
82(4):1498-508.
PMID: 20108906
Fast, sensitive, robust methods for "high-level" glycan screening are necessary during various stages of a biotherapeutic product's lifecycle, including clone selection, process changes, and quality control for lot release testing....
4.
Zhang B, Harder A, Connelly H, Maheu L, Cockrill S
Anal Chem
. 2009 Dec;
82(3):1090-9.
PMID: 20039682
The detection and characterization of unexpected disulfide-mediated structural variants of human immunoglobulin G2 (IgG2) antibodies was recently the subject of two copublications. In this paper, we present data to confirm...
5.
Zhang B, Cockrill S
Anal Chem
. 2009 Sep;
81(17):7314-20.
PMID: 19715362
We report the development and application of a method for determining bonding patterns in disulfide-linked peptides containing closely spaced cysteine residues. Through the utility of classic N-terminal sequencing chemistry coupled...
6.
Prater B, Connelly H, Qin Q, Cockrill S
Anal Biochem
. 2008 Nov;
385(1):69-79.
PMID: 19000897
We present an optimized high-throughput method for the characterization of 2-aminobenzamide (2-AB)-labeled N-glycans from recombinant immunoglobulin G (rIgG). This method includes an optimized sample preparation protocol involving microwave-assisted deglycosylation in...
7.
Schuchard M, Mehigh R, Cockrill S, Lipscomb G, Stephan J, Wildsmith J, et al.
Biotechniques
. 2005 Aug;
39(2):239-47.
PMID: 16116797
The inclusion of protease inhibitors in serum or plasma samples has been found to significantly impact the isoform profile of selected plasma proteins as seen on 2-dimensional electrophoresis (2-DE) gels....
8.
Rai A, Gelfand C, Haywood B, Warunek D, Yi J, Schuchard M, et al.
Proteomics
. 2005 Jul;
5(13):3262-77.
PMID: 16052621
There is a substantial list of pre-analytical variables that can alter the analysis of blood-derived samples. We have undertaken studies on some of these issues including choice of sample type,...
9.
Kwiterovich Jr P, Cockrill S, Virgil D, Garrett E, Otvos J, Knight-Gibson C, et al.
JAMA
. 2005 Apr;
293(15):1891-9.
PMID: 15840864
Context: Low birth weight is associated with increased cardiovascular disease in adulthood, and differences in the molecular weight, composition, and quantity of lipoprotein subclasses are associated with coronary artery disease....
10.
Cockrill S, Foster K, Wildsmith J, Goodrich A, Dapron J, Hassell T, et al.
Biotechniques
. 2005 Feb;
38(2):301-4.
PMID: 15727137
A method is presented for the recovery and subsequent guanidination of tryptic peptides from samples previously spotted on a matrix-assisted laser desorption/ionization (MALDI) target. The procedure is shown to have...