Steven E Pfeiffer
Overview
Explore the profile of Steven E Pfeiffer including associated specialties, affiliations and a list of published articles.
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Articles
17
Citations
433
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Recent Articles
1.
Bergman C, Marta C, Maric M, Pfeiffer S, Cresswell P, Ruddle N
J Immunol
. 2012 May;
188(12):6001-9.
PMID: 22586035
IFN-γ-inducible lysosomal thiol reductase (GILT) is an enzyme located in the Lamp-2-positive compartments of APC. GILT(-/-) mice are phenotypically normal, but their T cells exhibit reduced proliferation to several exogenously...
2.
Ma J, Tanaka K, Shimizu T, Bernard C, Kakita A, Takahashi H, et al.
J Neurosci Res
. 2011 Feb;
89(5):639-49.
PMID: 21344476
Demyelination coincides with numerous changes of gene expression in the central nervous system (CNS). Cystatin F, which is a papain-like lysosomal cysteine proteinase inhibitor that is normally expressed by immune...
3.
Fewou S, Fernandes A, Stockdale K, Francone V, Dupree J, Rosenbluth J, et al.
J Neurochem
. 2009 Nov;
112(3):599-610.
PMID: 19878436
Myelin is highly enriched in galactocerebroside (GalCer) and its sulfated form sulfatide. Mice, unable to synthesize GalCer and sulfatide (CGT(null)) or sulfatide alone (CST(null)), exhibit disorganized paranodal structures and progressive...
4.
Ishii A, Dutta R, Wark G, Hwang S, Han D, Trapp B, et al.
Proc Natl Acad Sci U S A
. 2009 Aug;
106(34):14605-10.
PMID: 19706548
Myelin, formed by oligodendrocytes (OLs) in the CNS, is critical for axonal functions, and its damage leads to debilitating neurological disorders such as multiple sclerosis. Understanding the molecular mechanisms of...
5.
Anitei M, Cowan A, Pfeiffer S, Bansal R
J Neurosci Res
. 2008 Sep;
87(2):342-52.
PMID: 18798275
Rab3a, a small GTPase important for exocytosis, is uniquely up-regulated as oligodendrocytes enter terminal differentiation and initiate myelin biosynthesis. In this study, we analyze the role of this protein in...
6.
Marta C, Bansal R, Pfeiffer S
J Neuroimmunol
. 2008 Apr;
196(1-2):35-40.
PMID: 18406472
Antibodies to myelin oligodendrocyte glycoprotein (MOG) have been implicated in Multiple Sclerosis demyelination through activation of complement and/or macrophage-effector processes. We presented a novel mechanism, whereby MOG on oligodendrocytes, when...
7.
Ishii A, Ikenaka K, Pfeiffer S
J Neurochem
. 2007 Dec;
103 Suppl 1:25-31.
PMID: 17986136
Understanding the rich complement of sugar chains found in cellular membranes is impeded by the complexity of cell types and membrane diversity. To overcome this, we have analyzed the N-linked...
8.
Anitei M, Pfeiffer S
Curr Biol
. 2006 Jun;
16(11):R418-21.
PMID: 16753556
Myelin biogenesis is a complex process involving coordinated exocytosis, endocytosis, mRNA transport and cytoskeletal dynamics. Recent studies indicate that soluble neuronal signals may control the surface expression of proteolipid protein,...
9.
Anitei M, Ifrim M, Ewart M, Cowan A, Carson J, Bansal R, et al.
J Cell Sci
. 2006 Feb;
119(Pt 5):807-18.
PMID: 16478790
In the central nervous system, oligodendrocytes synthesize vast amounts of myelin, a multilamellar membrane wrapped around axons that dramatically enhances nerve transmission. A complex apparatus appears to coordinate trafficking of...
10.
Marta C, Oliver A, Sweet R, Pfeiffer S, Ruddle N
Proc Natl Acad Sci U S A
. 2005 Sep;
102(39):13992-7.
PMID: 16172404
Antibodies to myelin components are routinely detected in multiple sclerosis patients. However, their presence in some control subjects has made it difficult to determine their contribution to disease pathogenesis. Immunization...