Steven E Jacobsen
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Explore the profile of Steven E Jacobsen including associated specialties, affiliations and a list of published articles.
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203
Citations
24664
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Recent Articles
1.
Yip A, Kim T, Peluso E, Jacobsen S, Yeh M, Lechner M
JCEM Case Rep
. 2025 Feb;
3(3):luaf002.
PMID: 39963300
Medullary thyroid carcinoma (MTC) is a rare neuroendocrine tumor of the thyroid parafollicular C-cells associated with activating mutations in the rearranged during transfection () kinase proto-oncogene. We report the clinical...
2.
Wang M, He Y, Zhong Z, Papikian A, Wang S, Gardiner J, et al.
Nat Plants
. 2025 Feb;
11(2):206-217.
PMID: 39934332
Patterning of DNA methylation in eukaryotic genomes is controlled by de novo methylation, maintenance mechanisms and demethylation pathways. In Arabidopsis thaliana, DNA demethylation enzymes are clearly important for shaping methylation...
3.
Boone B, Mendoza C, Behrendt N, Jacobsen S
Epigenomes
. 2024 Sep;
8(3).
PMID: 39311135
Proteins are localized and concentrated at cellular and genomic locations for specific and efficient functions. Efforts to understand protein accumulation in eukaryotic organisms have primarily focused on multivalent interactions between...
4.
McDonald B, Picard C, Brabb I, Savenkova M, Schmitz R, Jacobsen S, et al.
Nat Plants
. 2024 Jul;
10(8):1246-1257.
PMID: 39080503
Unstable transcripts have emerged as markers of active enhancers in vertebrates and shown to be involved in many cellular processes and medical disorders. However, their prevalence and role in plants...
5.
Harris C, Zhong Z, Ichino L, Feng S, Jacobsen S
Elife
. 2024 May;
12.
PMID: 38814684
Silencing pathways prevent transposable element (TE) proliferation and help to maintain genome integrity through cell division. Silenced genomic regions can be classified as either euchromatic or heterochromatic, and are targeted...
6.
Wang S, Wang M, Ichino L, Boone B, Zhong Z, Papareddy R, et al.
Nat Plants
. 2024 Jan;
10(1):13-24.
PMID: 38225352
DNA methylation is an essential component of transposable element (TE) silencing, yet the mechanism by which methylation causes transcriptional repression remains poorly understood. Here we study the Arabidopsis thaliana Methyl-CpG...
7.
Wang Z, Castillo-Gonzalez C, Zhao C, Tong C, Li C, Zhong S, et al.
Nat Commun
. 2023 Nov;
14(1):7484.
PMID: 37980416
The H3 methyltransferases ATXR5 and ATXR6 deposit H3.1K27me1 to heterochromatin to prevent genomic instability and transposon re-activation. Here, we report that atxr5 atxr6 mutants display robust resistance to Geminivirus. The...
8.
Boone B, Ichino L, Wang S, Gardiner J, Yun J, Jami-Alahmadi Y, et al.
Sci Adv
. 2023 Nov;
9(46):eadi9036.
PMID: 37967186
DNA methylation mediates silencing of transposable elements and genes in part via recruitment of the Arabidopsis MBD5/6 complex, which contains the methyl-CpG binding domain (MBD) proteins MBD5 and MBD6, and...
9.
Yan C, Han W, Zhou Q, Niwa K, Tang M, Burch J, et al.
J Am Chem Soc
. 2023 Nov;
145(46):25080-25085.
PMID: 37948671
Comparison of biosynthetic gene clusters (BGCs) found in devastating plant pathogens and biocontrol fungi revealed an uncharacterized and conserved polyketide BGC. Genome mining identified the associated metabolite to be treconorin,...
10.
McDonald B, Picard C, Brabb I, Savenkova M, Schmitz R, Jacobsen S, et al.
bioRxiv
. 2023 Oct;
PMID: 37808859
Unstable transcripts have emerged as markers of active enhancers in vertebrates and shown to be involved in many cellular processes and medical disorders. However, their prevalence and role in plants...