Steven D Morley
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Explore the profile of Steven D Morley including associated specialties, affiliations and a list of published articles.
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20
Citations
238
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Recent Articles
1.
Jacobs A, Morley S, Samuel K, Morgan K, Boswell L, Kendall T, et al.
World J Gastroenterol
. 2024 Aug;
30(31):3705-3716.
PMID: 39192998
Background: Metabolic dysfunction-associated steatotic liver disease (MASLD), characterised by hepatic lipid accumulation, causes inflammation and oxidative stress accompanied by cell damage and fibrosis. Liver injury (LI) is also frequently reported...
2.
Morgan K, Morley S, Raja A, Vandeputte M, Samuel K, Waterfall M, et al.
J Clin Med
. 2023 Jun;
12(12).
PMID: 37373688
The gut-liver axis is defined by dietary and environmental communication between the gut, microbiome and the liver with its redox and immune systems, the overactivation of which can lead to...
3.
Innes C, Henshall D, Wilson B, Poon M, Morley S, Ritchie S
Diabet Med
. 2022 Jun;
39(10):e14902.
PMID: 35716029
Background: The Dose Adjustment for Normal Eating (DAFNE) course teaches insulin dose adjustment to match dietary carbohydrates and improve glycaemic control in participants with type 1 diabetes mellitus (T1DM). We...
4.
Oxygen Plasma Substrate and Specific Nanopattern Promote Early Differentiation of HepaRG Progenitors
Morgan K, Bryans A, Brzeszczynski F, Samuel K, Treskes P, Brzeszczynska J, et al.
Tissue Eng Part A
. 2020 Apr;
26(19-20):1064-1076.
PMID: 32292123
Fully differentiated HepaRG™ cells are the hepatic cell line of choice for study in toxicology and drug trials. They are derived from a hepatoblast-like progenitor (HepaRG-P) that differentiates into a...
5.
Brzeszczynska J, Brzeszczynski F, Samuel K, Morgan K, Morley S, Plevris J, et al.
Cells
. 2020 Apr;
9(3).
PMID: 32245194
Gene expression analysis by quantitative real-time polymerase chain reaction (RT-qPCR) is routinely used in biomedical studies. The reproducibility and reliability of the data fundamentally depends on experimental design and data...
6.
Morgan K, Gamal W, Samuel K, Morley S, Hayes P, Bagnaninchi P, et al.
J Clin Med
. 2019 Dec;
9(1).
PMID: 31878354
There are a variety of end-point assays and techniques available to monitor hepatic cell cultures and study toxicity within in vitro models. These commonly focus on one aspect of cell...
7.
West J, Mort R, Hill R, Morley S, Collinson J
Stem Cell Res
. 2018 May;
30:1-11.
PMID: 29777801
The use of mice that are mosaic for reporter gene expression underlies many lineage-tracing studies in stem cell biology. For example, using mosaic LacZ reporter mice, it was shown that...
8.
Yeung E, Treskes P, Martin S, Manning J, Dunbar D, Rogers S, et al.
Lipids Health Dis
. 2016 Aug;
15(1):125.
PMID: 27480541
No abstract available.
9.
Nelson L, Navarro M, Treskes P, Samuel K, Tura-Ceide O, Morley S, et al.
Sci Rep
. 2015 Dec;
5:17455.
PMID: 26632255
Organotypic liver culture models for hepatotoxicity studies that mimic in vivo hepatic functionality could help facilitate improved strategies for early safety risk assessment during drug development. Interspecies differences in drug...
10.
Yeung E, Treskes P, Martin S, Manning J, Dunbar D, Rogers S, et al.
Lipids Health Dis
. 2015 Aug;
14:86.
PMID: 26256740
Background: Cardiovascular disease (CVD) remains the major cause of excess mortality in patients with non-alcoholic fatty liver disease (NAFLD). The aim of this study was to investigate the individual contribution...