Steve S W Han
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Explore the profile of Steve S W Han including associated specialties, affiliations and a list of published articles.
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11
Citations
1091
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Recent Articles
1.
Schwartz J, Podell E, Han S, Berry J, Eggan K, Cech T
Mol Biol Cell
. 2014 Jul;
25(17):2571-8.
PMID: 25009283
Mutations in the RNA-binding protein FUS have been shown to cause the neurodegenerative disease amyotrophic lateral sclerosis (ALS). We investigate whether mutant FUS protein in ALS patient-derived fibroblasts affects normal...
2.
Wainger B, Kiskinis E, Mellin C, Wiskow O, Han S, Sandoe J, et al.
Cell Rep
. 2014 Apr;
7(1):1-11.
PMID: 24703839
Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disease of the motor nervous system. We show using multielectrode array and patch-clamp recordings that hyperexcitability detected by clinical neurophysiological studies of...
3.
Alami N, Smith R, Carrasco M, Williams L, Winborn C, Han S, et al.
Neuron
. 2014 Feb;
81(3):536-543.
PMID: 24507191
The RNA-binding protein TDP-43 regulates RNA metabolism at multiple levels, including transcription, RNA splicing, and mRNA stability. TDP-43 is a major component of the cytoplasmic inclusions characteristic of amyotrophic lateral...
4.
Han S, Williams L, Eggan K
Neuron
. 2011 May;
70(4):626-44.
PMID: 21609821
Among the disciplines of medicine, the study of neurological disorders is particularly challenging. The fundamental inaccessibility of the human neural types affected by disease prevents their isolation for in vitro...
5.
Li P, Tessler A, Han S, Fischer I, Rao M, Selzer M
Arch Neurol
. 2005 Feb;
62(2):223-9.
PMID: 15710850
Background: Replacement of neurons and glia by transplantation has been proposed as a therapy for neurodegenerative diseases, including amyotrophic lateral sclerosis. This strategy requires using human motor neuronal progenitor cells...
6.
Tobias C, Han S, Shumsky J, Kim D, Tumolo M, Dhoot N, et al.
J Neurotrauma
. 2005 Jan;
22(1):138-56.
PMID: 15665609
Encapsulation of cells has the potential to provide a protective barrier against host immune cell interactions after grafting. Previously we have shown that alginate encapsulated BDNF-producing fibroblasts (Fb/BDNF) survived for...
7.
Liu Y, Han S, Wu Y, Tuohy T, Xue H, Cai J, et al.
Dev Biol
. 2004 Nov;
276(1):31-46.
PMID: 15531362
The precise lineage between neural stem cells and mature astrocytes remains poorly defined. To examine astrocyte development, we have characterized glial precursors from neural tissue derived from early embryonic ages....
8.
Han S, Liu Y, Tyler-Polsz C, Rao M, Fischer I
Glia
. 2003 Dec;
45(1):1-16.
PMID: 14648541
Glial-restricted precursor (GRP) cells are among a number of candidate cells for transplantation repair of CNS injury. The isolation and characterization of these cells in vitro have been described previously,...
9.
Han S, Kang D, Mujtaba T, Rao M, Fischer I
Exp Neurol
. 2002 Nov;
177(2):360-75.
PMID: 12429183
Multipotent neural stem cells (NSCs) have the potential to differentiate into neuronal and glial cells and are therefore candidates for cell replacement after CNS injury. Their phenotypic fate in vivo...
10.
Wu Y, Mujtaba T, Han S, Fischer I, Rao M
Glia
. 2002 Mar;
38(1):65-79.
PMID: 11921204
Neuroepithelial stem cells (NEPs), glial-restricted precursors (GRPs), and neuron-restricted precursors (NRPs) are present during early differentiation of the spinal cord and can be identified by cell surface markers. In this...