Steve Gentleman
Overview
Explore the profile of Steve Gentleman including associated specialties, affiliations and a list of published articles.
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27
Citations
1327
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Recent Articles
1.
Otero-Jimenez M, Wojewska M, Binding L, Jogaudaite S, Gray-Rodriguez S, Young A, et al.
Acta Neuropathol Commun
. 2025 Feb;
13(1):25.
PMID: 39934841
Alpha-synucleinopathies are neurodegenerative diseases characterized by the spread of alpha-synuclein (α-syn) aggregates throughout the central nervous system in a stereotypical manner. These diseases include Lewy body disease (LBD), which encompass...
2.
Nowell J, Gentleman S, Edison P
J Neurol Neurosurg Psychiatry
. 2024 Nov;
PMID: 39603675
Background: It remains imperative to discover the time course that cardiovascular risk factors influence neurodegeneration in males and females and decipher whether the apolipoprotein (APOE) genotype mediates this relationship. Here...
3.
Kovacs G, Grinberg L, Halliday G, Alafuzoff I, Dugger B, Murayama S, et al.
Mov Disord
. 2024 Oct;
39(12):2173-2179.
PMID: 39360851
No abstract available.
4.
Nowell J, Raza S, Livingston N, Sivanathan S, Gentleman S, Edison P
J Alzheimers Dis
. 2024 Sep;
101(3):987-999.
PMID: 39302365
Background: Tau aggregation demonstrates close associations with hypometabolism in Alzheimer's disease (AD), although differing pathophysiological processes may underlie their development. Objective: To establish whether tau deposition and glucose metabolism have...
5.
Tang J, Huang H, Muirhead R, Zhou Y, Li J, DeFelice J, et al.
Brain Commun
. 2024 Jul;
6(4):fcae218.
PMID: 39035420
Amyloid-β pathology and neurofibrillary tangles lead to glial activation and neurodegeneration in Alzheimer's disease. In this study, we investigated the relationships between the levels of amyloid-β oligomers, amyloid-β plaques, glial...
6.
Leng F, Hinz R, Gentleman S, Dani M, Brooks D, Edison P
J Alzheimers Dis
. 2024 Jul;
100(3):973-986.
PMID: 39031352
Background: Neuroinflammation in Alzheimer's disease is known as an important process in the disease, yet how microglial activation affects disease progression remains unclear. Objective: The current study aims to interrogate...
7.
Tauber C, Schwarz S, Rosler T, Arzberger T, Gentleman S, Windl O, et al.
Acta Neuropathol Commun
. 2023 Mar;
11(1):40.
PMID: 36906636
The MAPT gene, encoding the microtubule-associated protein tau on chromosome 17q21.31, is result of an inversion polymorphism, leading to two allelic variants (H1 and H2). Homozygosity for the more common...
8.
Ramsay D, Miller A, Baykeens B, Hassan H, Gentleman S
Cureus
. 2023 Mar;
15(1):e34279.
PMID: 36855480
Football (soccer) is the most widely played sport across the globe. Due to some recent high-profile cases and epidemiological studies suggesting football can lead to neurodegeneration, scientific and public interest...
9.
Leng F, Hinz R, Gentleman S, Hampshire A, Dani M, Brooks D, et al.
Mol Psychiatry
. 2022 Dec;
28(3):1303-1311.
PMID: 36474000
Brain network dysfunction is increasingly recognised in Alzheimer's disease (AD). However, the causes of brain connectivity disruption are still poorly understood. Recently, neuroinflammation has been identified as an important factor...
10.
Livingston N, Calsolaro V, Hinz R, Nowell J, Raza S, Gentleman S, et al.
Mol Psychiatry
. 2022 Feb;
27(4):2019-2029.
PMID: 35125495
Post mortem neuropathology suggests that astrocyte reactivity may play a significant role in neurodegeneration in Alzheimer's disease. We explored this in vivo using multimodal PET and MRI imaging. Twenty subjects...