Stephen T ORourke
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Explore the profile of Stephen T ORourke including associated specialties, affiliations and a list of published articles.
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37
Citations
533
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Recent Articles
1.
Anto S, Sun C, ORourke S
J Cardiovasc Pharmacol
. 2025 Jan;
PMID: 39836102
Receptors for the vasoactive adipokine apelin, termed APJ receptors, are G-protein-coupled receptors and are widely expressed throughout the cardiovascular system. APJ receptors can also signal via G-protein-independent pathways, including G-protein-coupled-receptor...
2.
Yao F, Niloy S, Shen Y, Zhang Q, ORourke S, Sun C
Biochem Biophys Res Commun
. 2023 Jul;
675:187.
PMID: 37524614
No abstract available.
3.
Niloy S, Shen Y, Guo L, ORourke S, Sun C
Int J Mol Sci
. 2023 Jul;
24(13).
PMID: 37446080
Mechanisms by which BK (large-conductance calcium-sensitive potassium) channels are involved in vascular remodeling in hypertension are not fully understood. Vascular smooth muscle cell (VSMC) proliferation and vascular morphology were compared...
4.
Yao F, Niloy S, Shen Y, Zhang Q, ORourke S, Sun C
Biochem Biophys Res Commun
. 2023 May;
665:202-207.
PMID: 37167808
Apelin and APJ receptor play an important role in the regulating cardiovascular function; however, conflicting results have been reported regarding the effect of apelin on cardiovascular regulation. In this study,...
5.
Zhang Q, Shen Y, Niloy S, ORourke S, Sun C
Pharmaceuticals (Basel)
. 2023 Apr;
16(4).
PMID: 37111357
Apelin, by stimulation of APJ receptors, induces transient blood pressure (BP) reduction and positive inotropic effects. APJ receptors share high homology with the Ang II type 1 receptor; thus, apelin...
6.
Anto S, Sathish V, Sun C, ORourke S
J Cardiovasc Pharmacol
. 2022 Aug;
80(6):842-851.
PMID: 35976142
Apelin, an endogenous ligand for APJ receptors, causes nitric oxide (NO)-dependent relaxation of coronary arteries. Little is known about the effects of apelin/APJ receptor signaling in the coronary circulation under...
7.
Lekatz L, Shukla P, ORourke S, Schauer C, Van Emon M, Maddock-Carlin K, et al.
Theriogenology
. 2022 Apr;
185:24-33.
PMID: 35367778
We hypothesized isocaloric diets low in protein would decrease the sensitivity of caruncular (CAR) and cotyledonary (COT) arteries compared to placental arteries from ewes receiving adequate metabolizable protein (MP) requirements....
8.
Peine J, Neville T, Jia G, Van Emon M, Kirsch J, Hammer C, et al.
J Anim Sci
. 2021 Nov;
99(11).
PMID: 34723341
Multiparous Rambouillet ewes (n = 32) were allocated in a completely randomized design to determine if rumen-protected L-arginine (RP-Arg) supplementation during mid- and late gestation would 1) alter maternal carotid...
9.
Mughal A, Sun C, ORourke S
Front Pharmacol
. 2021 Jun;
12:679005.
PMID: 34122102
Apelin-APJ receptor signaling regulates vascular tone in cerebral and peripheral arteries. We recently reported that apelin inhibits BK channel function in cerebral arteries, resulting in impaired endothelium-dependent relaxations. In contrast,...
10.
Zhong T, Wang Z, Niloy S, Shen Y, ORourke S, Sun C
Front Pharmacol
. 2021 Mar;
12:608523.
PMID: 33664668
Cardiac hypertrophy is an adaptive response to cardiac overload initially but turns into a decompensated condition chronically, leading to heart failure and sudden cardiac death. The molecular mechanisms involved in...