Stephen T Guest
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Explore the profile of Stephen T Guest including associated specialties, affiliations and a list of published articles.
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10
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185
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Recent Articles
1.
Turner-Ivey B, Fromm Longo J, Jenkins D, Guest S, Carroll S
J Vis Exp
. 2023 Sep;
(198).
PMID: 37677047
Malignant Peripheral Nerve Sheath Tumors (MPNSTs) are derived from Schwann cells or their precursors. In patients with the tumor susceptibility syndrome neurofibromatosis type 1 (NF1), MPNSTs are the most common...
2.
Development and implementation of the SUM breast cancer cell line functional genomics knowledge base
Ethier S, Guest S, Garrett-Mayer E, Armeson K, Wilson R, Duchinski K, et al.
NPJ Breast Cancer
. 2020 Jul;
6:30.
PMID: 32715085
Several years ago, the SUM panel of human breast cancer cell lines was developed, and these cell lines have been distributed to hundreds of labs worldwide. Our lab and others...
3.
Rutkovsky A, Yeh E, Guest S, Findlay V, Muise-Helmericks R, Armeson K, et al.
BMC Cancer
. 2019 May;
19(1):491.
PMID: 31122207
Background: Eukaryotic Initiation Factor 4E-Binding Protein (EIF4EBP1, 4EBP1) is overexpressed in many human cancers including breast cancer, yet the role of 4EBP1 in breast cancer remains understudied. Despite the known...
4.
Homer-Bouthiette C, Zhao Y, Shunkwiler L, Van Peel B, Garrett-Mayer E, Baird R, et al.
BMC Cancer
. 2018 Dec;
18(1):1233.
PMID: 30526553
Background: The gene desert on human chromosomal band 8q24 harbors multiple genetic variants associated with common cancers, including breast cancer. The locus, including the gene desert and its flanking genes,...
5.
Guest S, Kratche Z, Irish J, Wilson R, Haddad R, Gray J, et al.
Oncotarget
. 2016 May;
7(24):36138-36153.
PMID: 27153554
A critical first step in the personalized approach to cancer treatment is the identification of activated oncogenes that drive each tumor. The Identification of driver oncogenes on a patient-by-patient basis...
6.
Irish J, Mills J, Turner-Ivey B, Wilson R, Guest S, Rutkovsky A, et al.
Mol Oncol
. 2016 Mar;
10(6):850-65.
PMID: 27005559
The 8p11-p12 amplicon occurs in approximately 15% of breast cancers in aggressive luminal B-type tumors. Previously, we identified WHSC1L1 as a driving oncogene from this region. Here, we demonstrate that...
7.
Guest S, Kratche Z, Bollig-Fischer A, Haddad R, Ethier S
Exp Cell Res
. 2015 Feb;
332(2):223-35.
PMID: 25704758
Gene amplification is a common mechanism of oncogene activation in cancer. Several large-scale efforts aimed at identifying the comprehensive set of genomic regions that are recurrently amplified in cancer have...
8.
Kappler C, Guest S, Irish J, Garrett-Mayer E, Kratche Z, Wilson R, et al.
Mol Oncol
. 2014 Dec;
9(2):527-43.
PMID: 25454348
A subset of triple negative breast cancer (TNBC) is characterized by overexpression of the epidermal growth factor receptor (EGFR) and loss of PTEN, and patients with these determinants have a...
9.
Turner-Ivey B, Guest S, Irish J, Kappler C, Garrett-Mayer E, Wilson R, et al.
Neoplasia
. 2014 Sep;
16(8):644-55.
PMID: 25220592
The chromosome 8p11-p12 amplicon is present in 12% to 15% of breast cancers, resulting in an increase in copy number and expression of several chromatin modifiers in these tumors, including...
10.
Guest S, Yu J, Liu D, Hines J, Kashat M, Finley Jr R
BMC Syst Biol
. 2011 May;
5:65.
PMID: 21548953
Background: Large-scale RNAi-based screens are playing a critical role in defining sets of genes that regulate specific cellular processes. Numerous screens have been completed and in some cases more than...