Stephen P J Macdonald
Overview
Explore the profile of Stephen P J Macdonald including associated specialties, affiliations and a list of published articles.
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26
Citations
383
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Recent Articles
1.
McGrath F, Francis A, Fatovich D, Macdonald S, Arendts G, Bosco A, et al.
Clin Exp Allergy
. 2021 Jul;
51(10):1310-1321.
PMID: 34228845
Background: Anaphylaxis is a severe, potentially life-threatening allergic reaction driven primarily by the activation of mast cells. We still fail to understand factors underlying reaction severity. Furthermore, there is currently...
2.
Barnes C, Fatovich D, Macdonald S, Alcock R, Spiro J, Briffa T, et al.
Heart
. 2021 Jan;
107(9):721-727.
PMID: 33436490
Objective: We tested the hypothesis that patients with a potential acute coronary syndrome (ACS) and very low levels of high-sensitivity cardiac troponin I can be efficiently and safely discharged from...
3.
Tang B, Shojaei M, Wang Y, Nalos M, McLean A, Afrasiabi A, et al.
BMJ Open
. 2021 Jan;
11(1):e044497.
PMID: 33408218
Introduction: Accurate triage is an important first step to effectively manage the clinical treatment of severe cases in a pandemic outbreak. In the current COVID-19 global pandemic, there is a...
4.
Smart L, Macdonald S, Bosio E, Fatovich D, Neil C, Arendts G
J Crit Care
. 2019 Apr;
52:33-39.
PMID: 30954691
Objective And Design: Hypertonic saline administered during fluid resuscitation may mitigate endothelial glycocalyx (EG) shedding and inflammation. The objective of this pilot randomised controlled trial was to measure the effect...
5.
Macdonald S, Keijzers G, Taylor D, Kinnear F, Arendts G, Fatovich D, et al.
Intensive Care Med
. 2018 Nov;
44(12):2070-2078.
PMID: 30382308
Purpose: To determine if a regimen of restricted fluids and early vasopressor compared to usual care is feasible for initial resuscitation of hypotension due to suspected sepsis. Methods: A prospective,...
6.
Francis A, Bosio E, Stone S, Fatovich D, Arendts G, Macdonald S, et al.
J Innate Immun
. 2018 Sep;
11(1):63-73.
PMID: 30189430
Background: We have previously identified the upregulation of the innate immune response, neutrophil activation, and apoptosis during anaphylaxis using a microarray approach. This study aimed to validate the differential gene...
7.
Smart L, Bosio E, Macdonald S, Dull R, Fatovich D, Neil C, et al.
J Crit Care
. 2018 Jun;
47:93-98.
PMID: 29936329
Purpose: Endocan, a component of the endothelial glycocalyx (EG), has been linked with respiratory failure in sepsis. This study explored the temporal patterns of three EG biomarkers, including endocan, and...
8.
Self W, Semler M, Bellomo R, Brown S, deBoisblanc B, Exline M, et al.
Ann Emerg Med
. 2018 May;
72(4):457-466.
PMID: 29753517
Prompt intravenous fluid therapy is a fundamental treatment for patients with septic shock. However, the optimal approach for administering intravenous fluid in septic shock resuscitation is unknown. Two competing strategies...
9.
Macdonald S, Kinnear F, Arendts G, Ho K, Fatovich D
Eur J Emerg Med
. 2018 Jan;
26(3):174-179.
PMID: 29346183
Objectives: Sepsis is acute organ dysfunction in the setting of infection. An accurate diagnosis is important to guide treatment and disposition. Tissue oxygen saturation (StO2) can be estimated noninvasively by...
10.
Macdonald S, Taylor D, Keijzers G, Arendts G, Fatovich D, Kinnear F, et al.
Trials
. 2017 Aug;
18(1):399.
PMID: 28851407
Background: Guidelines recommend an initial intravenous (IV) fluid bolus of 30 ml/kg isotonic crystalloid for patients with sepsis and hypotension. However, there is a lack of evidence from clinical trials...