Stephen Lenzini
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Explore the profile of Stephen Lenzini including associated specialties, affiliations and a list of published articles.
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12
Citations
255
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Recent Articles
1.
Kim S, Kim Y, Kim S, Choi Y, Lee I, Joo H, et al.
Nat Commun
. 2025 Feb;
16(1):1903.
PMID: 39988725
Acute liver failure (ALF) is a life-threatening condition caused by rapid hepatocyte death and impaired liver regeneration. Here we show that extracellular vesicles engineered to express Signal Regulatory Protein Alpha...
2.
Akhter M, Yazbeck P, Tauseef M, Anwar M, Hossen F, Datta S, et al.
Cell Rep
. 2024 Jun;
43(6):114297.
PMID: 38824643
The mechanical environment generated through the adhesive interaction of endothelial cells (ECs) with the matrix controls nuclear tension, preventing aberrant gene synthesis and the transition from restrictive to leaky endothelium,...
3.
Debnath K, Las Heras K, Rivera A, Lenzini S, Shin J
Nat Rev Mater
. 2024 Mar;
8(6):390-402.
PMID: 38463907
The extracellular matrix in microenvironments harbors a variety of signals to control cellular functions and the materiality of tissues. Most efforts to synthetically reconstitute the matrix by biomaterial design have...
4.
Cho I, Gupta P, Mostafazadeh N, Wong S, Saichellappa S, Lenzini S, et al.
Adv Sci (Weinh)
. 2022 Dec;
10(3):e2206014.
PMID: 36453581
Various signals in tissue microenvironments are often unevenly distributed around cells. Cellular responses to asymmetric cell-matrix adhesion in a 3D space remain generally unclear and are to be studied at...
5.
Lenzini S, Debnath K, Joshi J, Wong S, Srivastava K, Geng X, et al.
ACS Nano
. 2021 Oct;
15(11):17439-17452.
PMID: 34677951
Extracellular vesicles (EVs) are cell-secreted particles with broad potential to treat tissue injuries by delivering cargo to program target cells. However, improving the yield of functional EVs on a per...
6.
Wong S, Lenzini S, Giovanni R, Knowles K, Shin J
Acta Biomater
. 2021 Aug;
133:126-138.
PMID: 34365041
Hydrogels have been used to design synthetic matrices that capture salient features of matrix microenvironments to study and control cellular functions. Recent advances in understanding of both extracellular matrix biology...
7.
Wong S, Lenzini S, Bargi R, Feng Z, Macaraniag C, Lee J, et al.
Adv Sci (Weinh)
. 2020 Oct;
7(20):2001066.
PMID: 33101850
Advances in engineered hydrogels reveal how cells sense and respond to 3D biophysical cues. However, most studies rely on interfacing a population of cells in a tissue-scale bulk hydrogel, an...
8.
Devine D, Vijayakumar V, Wong S, Lenzini S, Newman P, Shin J
Adv Biosyst
. 2020 Oct;
4(11):e2000012.
PMID: 33053274
The extracellular matrix varies considerably in mechanical properties at the microscale. It remains unclear how cells respond to these properties, in part, due to lack of tools to create precisely...
9.
Wong S, Lenzini S, Cooper M, Mooney D, Shin J
Sci Adv
. 2020 Apr;
6(15):eaaw0158.
PMID: 32284989
Mesenchymal stromal cells (MSCs) modulate immune cells to ameliorate multiple inflammatory pathologies. Biophysical signals that regulate this process are poorly defined. By engineering hydrogels with tunable biophysical parameters relevant to...
10.
Lenzini S, Bargi R, Chung G, Shin J
Nat Nanotechnol
. 2020 Feb;
15(3):217-223.
PMID: 32066904
Cells release extracellular vesicles (EVs) to communicate over long distances, which requires EVs to traverse the extracellular matrix (ECM). However, given that the size of EVs is usually larger than...