Stephen K Wu
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Explore the profile of Stephen K Wu including associated specialties, affiliations and a list of published articles.
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5
Citations
129
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Recent Articles
1.
Balas M, Hartwick E, Barrington C, Roberts J, Wu S, Bettcher R, et al.
Sci Adv
. 2021 Apr;
7(16).
PMID: 33853770
Human Polycomb Repressive Complex 2 (PRC2) catalysis of histone H3 lysine 27 methylation at certain loci depends on long noncoding RNAs (lncRNAs). Yet, in apparent contradiction, RNA is a potent...
2.
Wu S, Roberts J, Balas M, Johnson A
Biochem Soc Trans
. 2020 Nov;
48(6):2467-2481.
PMID: 33245317
Beyond being the product of gene expression, RNA can also influence the regulation of chromatin. The majority of the human genome has the capacity to be transcribed and the majority...
3.
Machlus K, Wu S, Vijey P, Soussou T, Liu Z, Shacham E, et al.
Blood
. 2017 Jun;
130(9):1132-1143.
PMID: 28630120
Selinexor is the first oral selective inhibitor of nuclear export compound tested for cancer treatment. Selinexor has demonstrated a safety therapy profile with broad antitumor activity against solid and hematological...
4.
Machlus K, Wu S, Stumpo D, Soussou T, Paul D, Campbell R, et al.
Blood
. 2016 Jan;
127(11):1468-80.
PMID: 26744461
Platelets are essential for hemostasis, and thrombocytopenia is a major clinical problem. Megakaryocytes (MKs) generate platelets by extending long processes, proplatelets, into sinusoidal blood vessels. However, very little is known...
5.
Machlus K, Johnson K, Kulenthirarajan R, Forward J, Tippy M, Soussou T, et al.
Blood
. 2015 Dec;
127(7):921-6.
PMID: 26647394
In times of physiological stress, platelet count can transiently rise. What initiates this reactive thrombocytosis is poorly understood. Intriguingly, we found that treating megakaryocytes (MKs) with the releasate from activated...