Stephen Frye
Overview
Explore the profile of Stephen Frye including associated specialties, affiliations and a list of published articles.
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Articles
12
Citations
1631
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0
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Recent Articles
1.
Muller S, Frye S, Baell J
RSC Med Chem
. 2022 Dec;
13(12):1438.
PMID: 36561071
Guest editors Susanne Müller, Stephen Frye and Jonathan Baell introduce the themed collection on chemical probes.
2.
Laufer S, Bajorath J, Gehringer M, Gray N, Frye S, Lindsley C
J Med Chem
. 2022 May;
65(10):6973-6974.
PMID: 35512193
No abstract available.
3.
Rohde J, Karavadhi S, Pragani R, Liu L, Fang Y, Zhang W, et al.
J Med Chem
. 2021 Apr;
64(8):4913-4946.
PMID: 33822623
Neomorphic mutations in isocitrate dehydrogenase 1 (IDH1) are oncogenic for a number of malignancies, primarily low-grade gliomas and acute myeloid leukemia. We report a medicinal chemistry campaign around a 7,7-dimethyl-7,8-dihydro-2-1λ-quinoline-2,5(6)-dione...
4.
Hoque M, Wong S, Recasens A, Abbassi R, Nguyen N, Zhang D, et al.
Biochem Pharmacol
. 2021 Feb;
186:114437.
PMID: 33571503
MerTK has been identified as a promising target for therapeutic intervention in glioblastoma. Genetic studies documented a range of oncogenic processes that MerTK targeting could influence, however robust pharmacological validation...
5.
Hopcraft S, Pattenden S, James L, Frye S, Dittmer D, Damania B
PLoS Pathog
. 2018 Sep;
14(9):e1007267.
PMID: 30212584
Kaposi's sarcoma-associated herpesvirus (KSHV) is the etiologic agent of three human malignancies, the endothelial cell cancer Kaposi's sarcoma, and two B cell cancers, Primary Effusion Lymphoma and multicentric Castleman's disease....
6.
Lee-Sherick A, Zhang W, Menachof K, Hill A, Rinella S, Kirkpatrick G, et al.
Oncotarget
. 2015 Mar;
6(9):6722-36.
PMID: 25762638
Mer and Flt3 receptor tyrosine kinases have been implicated as therapeutic targets in acute myeloid leukemia (AML). In this manuscript we describe UNC1666, a novel ATP-competitive small molecule tyrosine kinase...
7.
Slusher B, Conn P, Frye S, Glicksman M, Arkin M
Nat Rev Drug Discov
. 2013 Nov;
12(11):811-2.
PMID: 24172316
The newly formed Academic Drug Discovery Consortium (ADDC) aims to support the growing numbers of university centres engaged in drug discovery that have emerged in response to recent changes in...
8.
Blancafort P, Jin J, Frye S
Mol Pharmacol
. 2012 Nov;
83(3):563-76.
PMID: 23150486
The epigenomic era has revealed a well-connected network of molecular processes that shape the chromatin landscape. These processes comprise abnormal methylomes, transcriptosomes, genome-wide histone post-transcriptional modifications patterns, histone variants, and...
9.
10.
Frye S, Crosby M, Edwards T, Juliano R
Nat Rev Drug Discov
. 2011 Jun;
10(6):409-10.
PMID: 21629285
No abstract available.