Stephen D Mague
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Explore the profile of Stephen D Mague including associated specialties, affiliations and a list of published articles.
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22
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Recent Articles
1.
Hughes D, Klein M, Walder-Christensen K, Thomas G, Grossman Y, Waters D, et al.
bioRxiv
. 2024 Jul;
PMID: 38979139
In rodents, anxiety is charactered by heightened vigilance during low-threat and uncertain situations. Though activity in the frontal cortex and limbic system are fundamental to supporting this internal state, the...
2.
Walder-Christensen K, Abdelaal K, Klein H, Thomas G, Gallagher N, Talbot A, et al.
Cell Rep Methods
. 2024 Jan;
4(1):100691.
PMID: 38215761
Therapeutic development for mental disorders has been slow despite the high worldwide prevalence of illness. Unfortunately, cellular and circuit insights into disease etiology have largely failed to generalize across individuals...
3.
Block C, Eroglu O, Mague S, Smith C, Ceasrine A, Sriworarat C, et al.
Cell Rep
. 2022 Aug;
40(5):111161.
PMID: 35926455
Gestational exposure to environmental toxins and socioeconomic stressors is epidemiologically linked to neurodevelopmental disorders with strong male bias, such as autism. We model these prenatal risk factors in mice by...
4.
Mague S, Talbot A, Blount C, Walder-Christensen K, Duffney L, Adamson E, et al.
Neuron
. 2022 Mar;
110(10):1728-1741.e7.
PMID: 35294900
The architecture whereby activity across many brain regions integrates to encode individual appetitive social behavior remains unknown. Here we measure electrical activity from eight brain regions as mice engage in...
5.
Hultman R, Ulrich K, Sachs B, Blount C, Carlson D, Ndubuizu N, et al.
Cell
. 2018 Mar;
173(1):166-180.e14.
PMID: 29502969
Brain-wide fluctuations in local field potential oscillations reflect emergent network-level signals that mediate behavior. Cracking the code whereby these oscillations coordinate in time and space (spatiotemporal dynamics) to represent complex...
6.
Carlson D, David L, Gallagher N, Vu M, Shirley M, Hultman R, et al.
Biol Psychiatry
. 2017 Jul;
82(12):904-913.
PMID: 28728677
Background: The prefrontal cortex plays a critical role in regulating emotional behaviors, and dysfunction of prefrontal cortex-dependent networks has been broadly implicated in mediating stress-induced behavioral disorders including major depressive...
7.
Hultman R, Mague S, Li Q, Katz B, Michel N, Lin L, et al.
Neuron
. 2016 Jun;
91(2):439-52.
PMID: 27346529
Circuits distributed across cortico-limbic brain regions compose the networks that mediate emotional behavior. The prefrontal cortex (PFC) regulates ultraslow (<1 Hz) dynamics across these networks, and PFC dysfunction is implicated...
8.
Wang X, Bey A, Katz B, Badea A, Kim N, David L, et al.
Nat Commun
. 2016 May;
7:11459.
PMID: 27161151
Human neuroimaging studies suggest that aberrant neural connectivity underlies behavioural deficits in autism spectrum disorders (ASDs), but the molecular and neural circuit mechanisms underlying ASDs remain elusive. Here, we describe...
9.
Mague S, Port R, McMullen M, Carlson G, Turner J
Neuropharmacology
. 2015 May;
97:426-35.
PMID: 25986698
A single nucleotide polymorphism (SNP) in the human μ-opioid receptor gene (OPRM1 A118G) has been widely studied for its association in a variety of drug addiction and pain sensitivity phenotypes;...
10.
Huang P, Chen C, Mague S, Blendy J, Liu-Chen L
Biochem J
. 2011 Aug;
441(1):379-86.
PMID: 21864297
The A118G SNP (single nucleotide polymorphism) of the hMOPR [human MOPR (μ opioid receptor)] gene OPRM1 results in an amino acid substitution (N40D). Subjects homozygous for the 118G allele have...