Stephen C Bunnell
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Explore the profile of Stephen C Bunnell including associated specialties, affiliations and a list of published articles.
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35
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1634
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Recent Articles
21.
Sacristan C, Schattgen S, Berg L, Bunnell S, Roy A, Rosenstein Y
Eur J Immunol
. 2009 Aug;
39(9):2584-95.
PMID: 19701889
TCR signaling leads to the activation of kinases such as inducible tyrosine kinase (Itk), a key regulatory protein in T-lymphocyte activation and function. The homolog of Itk in B cells...
22.
Marko M, Pang H, Ren Z, Azzi A, Huber B, Bunnell S, et al.
J Nutr
. 2009 May;
139(6):1192-7.
PMID: 19403707
Supplemental vitamin E alleviates age-related defects in interleukin (IL)-2 production, T cell proliferation, and immune synapse formation. Here, we evaluated the effect of in vitro supplementation with 46 mumol/L of...
23.
Nguyen K, Sylvain N, Bunnell S
Immunity
. 2008 Jun;
28(6):810-21.
PMID: 18549800
Antigen-dependent T cell activation drives the formation of signaling microclusters containing the adaptor SLP-76. Costimulatory integrins regulate SLP-76 phosphorylation and could influence SLP-76 microclusters in the integrin-rich periphery of the...
24.
Seminario M, Bunnell S
Immunol Rev
. 2008 Feb;
221:90-106.
PMID: 18275477
Although dynamic imaging technologies have provided important insights into the underlying processes responsible for T-cell activation, the processes that link antigen recognition to downstream signaling remain poorly defined. Converging lines...
25.
Marko M, Ahmed T, Bunnell S, Wu D, Chung H, Huber B, et al.
J Immunol
. 2007 Jan;
178(3):1443-9.
PMID: 17237392
Aging is associated with reduced IL-2 production and T cell proliferation. Vitamin E supplementation, in aged animals and humans, increases cell division and IL-2 production by naive T cells. The...
26.
Morley S, Sung J, Sun G, Martelli M, Bunnell S, Bierer B
Mol Immunol
. 2006 Dec;
44(9):2469-80.
PMID: 17178161
Upon T cell receptor engagement, both the actin cytoskeleton and substrates of tyrosine phosphorylation are remodeled to create a signaling complex at the interface of the antigen-presenting cell and responding...
27.
Bunnell S, Singer A, Hong D, Jacque B, Jordan M, Seminario M, et al.
Mol Cell Biol
. 2006 Sep;
26(19):7155-66.
PMID: 16980618
Antigen recognition triggers the recruitment of the critical adaptor protein SLP-76 to small macromolecular clusters nucleated by the T-cell receptor (TCR). These structures develop rapidly, in parallel with TCR-induced increases...
28.
Barr V, Balagopalan L, Barda-Saad M, Polishchuk R, Boukari H, Bunnell S, et al.
Traffic
. 2006 Aug;
7(9):1143-62.
PMID: 16919152
T-cell antigen receptor engagement causes the rapid assembly of signaling complexes. The adapter protein SLP-76, detected as SLP-yellow fluorescent protein, initially clustered with the TCR and other proteins, then translocated...
29.
Zipfel P, Bunnell S, Witherow D, Gu J, Chislock E, Ring C, et al.
Curr Biol
. 2006 Jan;
16(1):35-46.
PMID: 16401422
Background: The molecular reorganization of signaling molecules after T cell receptor (TCR) activation is accompanied by polymerization of actin at the site of contact between a T cell and an...
30.
Barda-Saad M, Braiman A, Titerence R, Bunnell S, Barr V, Samelson L
Nat Immunol
. 2004 Nov;
6(1):80-9.
PMID: 15558067
T cell receptor (TCR) engagement leads to actin polymerization at the site of T cell contact with antigen-presenting cells. Here we have studied the dynamic activity of proteins involved in...