Stephen A Wells
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Explore the profile of Stephen A Wells including associated specialties, affiliations and a list of published articles.
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31
Citations
277
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Recent Articles
1.
Wells S, Cessford N, Seaton N, Duren T
RSC Adv
. 2022 May;
9(25):14382-14390.
PMID: 35519296
Metal-organic frameworks (MOF) comprising metal nodes bridged by organic linkers show great promise because of their guest-specific gas sorption, separation, drug-delivery, and catalytic properties. The selection of metal node, organic...
2.
Noby N, Auhim H, Winter S, Worthy H, Embaby A, Saeed H, et al.
Open Biol
. 2021 Dec;
11(12):210182.
PMID: 34847772
Here we determined the structure of a cold active family IV esterase (EstN7) cloned strain N1. EstN7 is a dimer with a classical α/β hydrolase fold. It has an acidic...
3.
Thompson M, Wells S, Duren T
J Chem Phys
. 2021 Jul;
154(24):244703.
PMID: 34241364
Cancer remains hard to treat, partially due to the non-specificity of chemotherapeutics. Metal-organic frameworks (MOFs) are promising carriers for targeted chemotherapy, yet, to date, there have been few detailed studies...
4.
Knight M, Woolley R, Kwok A, Parsons S, Jones H, Gulacsy C, et al.
Biochem J
. 2020 Sep;
477(18):3599-3612.
PMID: 32869839
Among the major challenges in the development of biopharmaceuticals are structural heterogeneity and aggregation. The development of a successful therapeutic monoclonal antibody (mAb) requires both a highly active and also...
5.
Nearchou A, Cornelius M, Jones Z, Collings I, Wells S, Raithby P, et al.
R Soc Open Sci
. 2019 Aug;
6(7):182158.
PMID: 31417704
Previous work has shown a strong correlation between zeolite framework flexibility and the nature of structural symmetry and phase transitions. However, there is little experimental data regarding this relationship, in...
6.
Madura F, Rizkallah P, Legut M, Holland C, Fuller A, Bulek A, et al.
Eur J Immunol
. 2019 May;
49(7):1052-1066.
PMID: 31091334
The HLA-A*02:01-restricted decapeptide EAAGIGILTV, derived from melanoma antigen recognized by T-cells-1 (MART-1) protein, represents one of the best-studied tumor associated T-cell epitopes, but clinical results targeting this peptide have been...
7.
Jones H, Crean R, Mullen A, Kendrick E, Bull S, Wells S, et al.
Biochemistry
. 2019 Apr;
58(18):2362-2372.
PMID: 30964996
There is an increasing realization that structure-based drug design may show improved success by understanding the ensemble of conformations accessible to an enzyme and how the environment affects this ensemble....
8.
Nearchou A, Cornelius M, Skelton J, Jones Z, Cairns A, Collings I, et al.
Molecules
. 2019 Feb;
24(3).
PMID: 30759754
The roles of organic additives in the assembly and crystallisation of zeolites are still not fully understood. This is important when attempting to prepare novel frameworks to produce new zeolites....
9.
Adjogatse E, Erskine P, Wells S, Kelly J, Wilden J, Chan A, et al.
Acta Crystallogr D Struct Biol
. 2018 Sep;
74(Pt 9):861-876.
PMID: 30198897
Two of the world's most neglected tropical diseases, human African trypanosomiasis (HAT) and Chagas disease, are caused by protozoan parasites of the genus Trypanosoma. These organisms possess specialized metabolic pathways,...
10.
Wells S, Leung K, Edwards P, Tucker M, Sartbaeva A
R Soc Open Sci
. 2017 Oct;
4(9):170757.
PMID: 28989777
The flexibility window in zeolites was originally identified using geometric simulation as a hypothetical property of SiO systems. The existence of the flexibility window in hypothetical structures may help us...